The adjunctive effect of rhBMP-2 on the regeneration of peri-implant bone defects after experimental peri-implantitis.
animal model
bone graft
collagen membrane
dental implants
experimental peri-implantitis
histology
histometric analysis
rhBMP-2
surgical regenerative therapy
Journal
Clinical oral implants research
ISSN: 1600-0501
Titre abrégé: Clin Oral Implants Res
Pays: Denmark
ID NLM: 9105713
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
28
03
2019
revised:
14
07
2019
accepted:
28
08
2019
pubmed:
13
9
2019
medline:
18
12
2019
entrez:
13
9
2019
Statut:
ppublish
Résumé
The aim was to evaluate the degree of bone regeneration and re-osseointegration attained when combining a xenogeneic bone replacement graft plus rhBMP-2 and a collagen membrane in ligature-induced peri-implantitis osseous defects in dogs. Thirty-six implants were placed in a total of 6 Beagle dogs, 3 months after tooth extraction. Once experimental peri-implantitis was induced, defects were randomly allocated into two treatment groups: in the test group guided bone regeneration was applied using de-proteinized bovine bone mineral with 10% collagen soak loaded with rhBMP2 covered with a natural collagen membrane. In the control group, the same scaffold and membrane were used but saline was used to soak the grafting material. After a period of 8 weeks of healing, a submerged environment clinical measurements were taken and histological outcomes were evaluated once the animals were euthanized. Histological bone defect regeneration (BR) was considered as the primary outcome variable, and dog was selected as the unit of analysis. Partial defect resolution was observed in both treatment groups. The histometric analysis showed a higher degree of bone regeneration for the test group, although differences were not statistically significant, both in terms of histological bone gain and percentage of re-osseointegration. (a) The addition of rhBMP2 to a bovine xenograft/collagen vehicle carrier failed to provide a significant added value in terms of bone regeneration or re-osseointegration, (b) partial re-osseointegration of a previously contaminated surface was achieved, although (c) a complete defect resolution and re-osseointegration to the level previous to the induction of the disease failed to occur in any of the treatment groups.
Substances chimiques
Dental Implants
0
Types de publication
Journal Article
Langues
eng
Pagination
1209-1219Subventions
Organisme : Complutense University
Organisme : University of Santiago de Compostela
Organisme : V Proclinic
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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