Synthesis and evaluation of the anti-hepatitis B virus activity of 4'-Azido-thymidine analogs and 4'-Azido-2'-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent.

Antiviral Agents / chemical synthesis Cytidine / analogs & derivatives Hep G2 Cells Hepatitis B virus / drug effects Humans Microbial Sensitivity Tests Molecular Conformation Stereoisomerism Zidovudine / analogs & derivatives
4′-azido nucleoside Anti-HBV nucleoside modified pyrimidines

Journal

Nucleosides, nucleotides & nucleic acids
ISSN: 1532-2335
Titre abrégé: Nucleosides Nucleotides Nucleic Acids
Pays: United States
ID NLM: 100892832

Informations de publication

Date de publication:
2020
Historique:
pubmed: 14 9 2019
medline: 15 12 2020
entrez: 14 9 2019
Statut: ppublish

Résumé

Hepatitis B virus (HBV) infection is a major worldwide health problem that requires the development of improved antiviral therapies. Here, a series of 4'-Azido-thymidine/4'-Azido-2'-deoxy-5-methylcytidine derivatives (

Identifiants

DOI: 10.1080/15257770.2019.1664749 PMID: 31514570 PMC: PMC8191380
pubmed: 31514570
doi: 10.1080/15257770.2019.1664749
pmc: PMC8191380
mid: NIHMS1704115
doi:

Substances chimiques

Antiviral Agents 0
4'-azidothymidine 130108-72-4
Zidovudine 4B9XT59T7S
Cytidine 5CSZ8459RP
5-methylcytidine TL9PB228DC

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

518-529

Subventions

Organisme : Intramural NIH HHS
ID : ZIA BC011486
Pays : United States

Références

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Auteurs

Kengo Onitsuka (K)

Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.

Ryoh Tokuda (R)

Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.

Nobuyo Kuwata-Higashi (N)

Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.

Hiroki Kumamoto (H)

Department of Pharmaceutical Sciences, Nihon Pharmaceutical University, Saitama, Japan.

Manabu Aoki (M)

Experimental Retrovirology Section, HIV & AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Masayuki Amano (M)

Departments of Infectious Diseases and Hematology, Kumamoto University School of Medicine, Kumamoto, Japan.

Satoru Kohgo (S)

Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.

Debananda Das (D)

Experimental Retrovirology Section, HIV & AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Kazuhiro Haraguchi (K)

Department of Pharmaceutical Sciences, Nihon Pharmaceutical University, Saitama, Japan.

Hiroaki Mitsuya (H)

Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
Experimental Retrovirology Section, HIV & AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Departments of Infectious Diseases and Hematology, Kumamoto University School of Medicine, Kumamoto, Japan.

Shuhei Imoto (S)

Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Synthesis and evaluation of the anti-hepatitis...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Cytidine › Synthesis and evaluation of the anti-hepatitis...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › Synthesis and evaluation of the anti-hepatitis...
questionsmedicales.fr › Virus › Virus de l'hépatite › Hepadnaviridae › Orthohepadnavirus › Virus de l'hépatite B › Synthesis and evaluation of the anti-hepatitis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis and evaluation of the anti-hepatitis...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Synthesis and evaluation of the anti-hepatitis...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Synthesis and evaluation of the anti-hepatitis...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Synthesis and evaluation of the anti-hepatitis...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléosides pyrimidiques › Thymidine › Zidovudine › Synthesis and evaluation of the anti-hepatitis...