Persistent clonal cytogenetic abnormality with del(20q) from an initial diagnosis of acute promyelocytic leukemia.
Acute promyelocytic leukemia
All-trans-retinoic acid
Clonal hematopoiesis
Cytopenia of undetermined significance (CCUS)
del(20q)
Journal
International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
15
04
2019
accepted:
04
09
2019
revised:
03
09
2019
pubmed:
14
9
2019
medline:
11
8
2020
entrez:
14
9
2019
Statut:
ppublish
Résumé
A 68-year-old male was diagnosed with acute promyelocytic leukemia (APL). A G-banding chromosomal analysis revealed the co-existence of two clones: one with del(20q) and t(15;17)(q22;q12) and another with del(20q) alone. During the remission of APL following treatment with all-trans-retinoic acid, del(20q) was persistently identified, indicating a diagnosis of cytogenetic abnormalities of undetermined significance (CCAUS) with isolated del(20q). Bicytopenia developed 48 months after the remission of APL. The presence of isolated del(20q) was detected in the G-banding analysis, whereas morphological dysplasia of hematopoietic cells was not confirmed. This case showed indolent progression from CCAUS after the remission of APL to clonal cytopenia of undetermined significance (CCUS). CCUS with isolated del(20q) persisted for 24 months without any finding of hematological malignancies. At the most recent follow-up, targeted capture sequencing showed the U2AF1 S34F mutation. Considerable attention needs to be paid in follow-ups for CCAUS with del(20q) after the treatment of leukemia.
Identifiants
pubmed: 31515708
doi: 10.1007/s12185-019-02731-w
pii: 10.1007/s12185-019-02731-w
doi:
Substances chimiques
Tretinoin
5688UTC01R
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
311-316Subventions
Organisme : Japan Society for the Promotion of Science
ID : #17K16189
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