Identification of anticancer drugs to radiosensitise
PARP inhibitor
Radiosensitizer
colorectal cancer
radiotherapy
Journal
Cancer biology & medicine
ISSN: 2095-3941
Titre abrégé: Cancer Biol Med
Pays: China
ID NLM: 101588850
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
entrez:
14
9
2019
pubmed:
14
9
2019
medline:
14
9
2019
Statut:
ppublish
Résumé
Patients with We screened 298 oncological drugs with and without ionising radiation in colorectal cancer cells isogenic for Most consistently identified hits were drugs targeting cell growth/proliferation or DNA damage repair. The most effective class of drugs that radiosensitised wild-type and mutant cell lines was PARP inhibitors. In clonogenic survival assays, talazoparib produced a radiation enhancement ratio of 1.9 in DLD1 ( Our method for screening large drug libraries for radiosensitisation has identified PARP inhibitors as promising radiosensitisers of colorectal cancer cells with wild-type and mutant
Identifiants
pubmed: 31516745
doi: 10.20892/j.issn.2095-3941.2018.0284
pii: cbm-16-2-234
pmc: PMC6713640
doi:
Types de publication
Journal Article
Langues
eng
Pagination
234-246Subventions
Organisme : Medical Research Council
ID : MC_PC_12006
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00001/6
Pays : United Kingdom
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