Francesca M Buffa

Affiliations

Computational Biology and Integrative Genomics Lab, MRC/CRUK Oxford Institute and Department of Oncology, University of Oxford, Oxford, UK. francesca.buffa@oncology.ox.ac.uk.

ORCID: http://orcid.org/0000-0003-0409-406X

Publications (24)

Guidelines for using sigQC for systematic evaluation of gene signatures.

Nature protocols

Avec: Andrew Dhawan , Alessandro Barberis , Wei-Chen Cheng , Enric Domingo , Catharine West , Tim Maughan , Jacob G Scott , Adrian L Harris , Francesca M Buffa

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

Cell death and differentiation

Avec: Zhuoyao Chen , Rafael M Ioris , Stacey Richardson , Ava N Van Ess , Iolanda Vendrell , Benedikt M Kessler , Francesca M Buffa , Luca Busino , Steven C Clifford , Alex N Bullock , Vincenzo D'Angiolella

Antitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models.

Cell death & disease

Avec: Gonzalo Rodriguez-Berriguete , Rathi Puliyadi , Nicole Machado , Alessandro Barberis , Remko Prevo , Martin McLaughlin , Francesca M Buffa , Kevin J Harrington , Geoff S Higgins

Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study.

PLoS computational biology

Avec: Pahala Gedara Jayathilake , Pedro Victori , Clara E Pavillet , Chang Heon Lee , Dimitrios Voukantsis , Ana Miar , Anjali Arora , Adrian L Harris , Karl J Morten , Francesca M Buffa

Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation.

Cell death & disease

Avec: Christos E Zois , Anne M Hendriks , Syed Haider , Elisabete Pires , Esther Bridges , Dimitra Kalamida , Dimitrios Voukantsis , B Christoffer Lagerholm , Rudolf S N Fehrmann , Wilfred F A den Dunnen , Andrei I Tarasov , Otto Baba , John Morris , Francesca M Buffa , James S O McCullagh , Mathilde Jalving , Adrian L Harris

Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells.

Cancer & metabolism

Avec: Masahiro Kawashima , Karim Bensaad , Christos E Zois , Alessandro Barberis , Esther Bridges , Simon Wigfield , Christoffer Lagerholm , Ruslan I Dmitriev , Mariko Tokiwa , Masakazu Toi , Dmitri B Papkovsky , Francesca M Buffa , Adrian L Harris

Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity.

Nucleic acids research

Avec: Samuel B Bader , Tiffany S Ma , Charlotte J Simpson , Jiachen Liang , Sakura Eri B Maezono , Monica M Olcina , Francesca M Buffa , Ester M Hammond

The impact of survivorship bias in glioblastoma research.

Critical reviews in oncology/hematology

Avec: Francesco Pasqualetti , Alessandro Barberis , Sofia Zanotti , Nicola Montemurro , Gian Luca De Salvo , Riccardo Soffietti , Chiara Maria Mazzanti , Tamara Ius , Maria Caffo , Fabiola Paiar , Guido Bocci , Giuseppe Lombardi , Adrian L Harris , Francesca M Buffa

MAGNETO: Cell type marker panel generator from single-cell transcriptomic data.

Journal of biomedical informatics

Avec: Andrea Tangherloni , Simone G Riva , Brynelle Myers , Francesca M Buffa , Paolo Cazzaniga

WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma.

Cellular oncology (Dordrecht)

Avec: Nicholas Coupe , Lina Guo , Esther Bridges , Leticia Campo , Olivia Espinosa , Richard Colling , Andrea Marshall , Ashwin Nandakumar , Ruud van Stiphout , Francesca M Buffa , Pippa G Corrie , Mark R Middleton , Valentine M Macaulay

Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network.

Journal of theoretical biology

Avec: Andrew Dhawan , Adrian L Harris , Francesca M Buffa , Jacob G Scott

Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism.

Molecular cancer research : MCR

Avec: Alessandro Valli , Matteo Morotti , Christos E Zois , Patrick K Albers , Tomoyoshi Soga , Katharina Feldinger , Roman Fischer , Martin Frejno , Alan McIntyre , Esther Bridges , Syed Haider , Francesca M Buffa , Dilair Baban , Miguel Rodriguez , Oscar Yanes , Hannah J Whittington , Hannah A Lake , Sevasti Zervou , Craig A Lygate , Benedikt M Kessler , Adrian L Harris

Identification of anticancer drugs to radiosensitise

Cancer biology & medicine

Avec: Rebecca Carter , Azadeh Cheraghchi-Bashi , Adam Westhorpe , Sheng Yu , Yasmin Shanneik , Elena Seraia , Djamila Ouaret , Yasuhiro Inoue , Catherine Koch , Jenny Wilding , Daniel Ebner , Anderson J Ryan , Francesca M Buffa , Ricky A Sharma

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin.

British journal of cancer

Avec: Simon R Lord , Jennifer M Collins , Wei-Chen Cheng , Syed Haider , Simon Wigfield , Edoardo Gaude , Barbara A Fielding , Katherine E Pinnick , Ulrike Harjes , Ashvina Segaran , Pooja Jha , Gerald Hoefler , Michael N Pollak , Alastair M Thompson , Pankaj G Roy , Ruth English , Rosie F Adams , Christian Frezza , Francesca M Buffa , Fredrik Karpe , Adrian L Harris

Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.

Journal of medical genetics

Avec: Matteo Di Giovannantonio , Benjamin Hl Harris , Ping Zhang , Isaac Kitchen-Smith , Lingyun Xiong , Natasha Sahgal , Giovanni Stracquadanio , Marsha Wallace , Sarah Blagden , Simon Lord , David Harris , Adrian H L Harris , Francesca M Buffa , Gareth L Bond

Radiogenomic analysis of primary breast cancer reveals [18F]-fluorodeoxglucose dynamic flux-constants are positively associated with immune pathways and outperform static uptake measures in associating with glucose metabolism.

Breast cancer research : BCR

Avec: G P Ralli , R D Carter , D R McGowan , W-C Cheng , D Liu , E J Teoh , N Patel , F Gleeson , A L Harris , S R Lord , F M Buffa , J D Fenwick

Robustness and reproducibility for AI learning in biomedical sciences: RENOIR.

Scientific reports

Avec: Alessandro Barberis , Hugo J W L Aerts , Francesca M Buffa

New perspectives in liquid biopsy for glioma patients.

Current opinion in oncology

Avec: Francesco Pasqualetti , Milena Rizzo , Sara Franceschi , Francesca Lessi , Fabiola Paiar , Francesca M Buffa

A machine learning and directed network optimization approach to uncover

iScience

Avec: Charalampos P Triantafyllidis , Alessandro Barberis , Fiona Hartley , Ana Miar Cuervo , Enio Gjerga , Philip Charlton , Linda van Bijsterveldt , Julio Saez Rodriguez , Francesca M Buffa

Role of gene signatures combined with pathology in classification of oropharynx head and neck cancer.

Scientific reports

Avec: Andrew Dhawan , Jacob Scott , Purnima Sundaresan , Michael Veness , Sandro Porceddu , Eric Hau , Adrian L Harris , Francesca M Buffa , Harriet E Gee

Correction to: Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells.

Cancer & metabolism

Modeling genotypes in their microenvironment to predict single- and multi-cellular behavior.

GigaScience

Avec: Dimitrios Voukantsis , Kenneth Kahn , Martin Hadley , Rowan Wilson , Francesca M Buffa

Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Michael Skwarski , Daniel R McGowan , Elizabeth Belcher , Francesco Di Chiara , Dionisios Stavroulias , Mark McCole , Jennifer L Derham , Kwun-Ye Chu , Eugene Teoh , Jagat Chauhan , Dawn O'Reilly , Benjamin H L Harris , Philip S Macklin , Joshua A Bull , Marcus Green , Gonzalo Rodriguez-Berriguete , Remko Prevo , Lisa K Folkes , Leticia Campo , Petra Ferencz , Paula L Croal , Helen Flight , Cathy Qi , Jane Holmes , James P B O'Connor , Fergus V Gleeson , W Gillies McKenna , Adrian L Harris , Daniel Bulte , Francesca M Buffa , Ruth E Macpherson , Geoff S Higgins

The MITF regulatory network in melanoma.

Pigment cell & melanoma research

Avec: Jagat S Chauhan , Michael Hölzel , Jean-Philippe Lambert , Francesca M Buffa , Colin R Goding

Réseau de co-auteurs

Adrian L Harris 11 collaborations

Alessandro Barberis 7 collaborations

Esther Bridges 5 collaborations

Christos E Zois 4 collaborations

Andrew Dhawan 3 collaborations

Dimitrios Voukantsis 3 collaborations

Syed Haider 3 collaborations

Simon Wigfield 3 collaborations

Wei-Chen Cheng 2 collaborations

Jacob G Scott 2 collaborations

Benedikt M Kessler 2 collaborations

Gonzalo Rodriguez-Berriguete 2 collaborations

Remko Prevo 2 collaborations

Geoff S Higgins 2 collaborations

Masahiro Kawashima 2 collaborations

Karim Bensaad 2 collaborations

Christoffer Lagerholm 2 collaborations

Ruslan I Dmitriev 2 collaborations

Mariko Tokiwa 2 collaborations

Masakazu Toi 2 collaborations

Dmitri B Papkovsky 2 collaborations

Francesco Pasqualetti 2 collaborations

Fabiola Paiar 2 collaborations

Leticia Campo 2 collaborations

Enric Domingo 1 collaboration

Catharine West 1 collaboration

Tim Maughan 1 collaboration

Zhuoyao Chen 1 collaboration

Rafael M Ioris 1 collaboration

Stacey Richardson 1 collaboration

Ava N Van Ess 1 collaboration

Iolanda Vendrell 1 collaboration

Luca Busino 1 collaboration

Steven C Clifford 1 collaboration

Alex N Bullock 1 collaboration

Vincenzo D'Angiolella 1 collaboration

Rathi Puliyadi 1 collaboration

Nicole Machado 1 collaboration

Martin McLaughlin 1 collaboration

Kevin J Harrington 1 collaboration

Pahala Gedara Jayathilake 1 collaboration

Pedro Victori 1 collaboration

Clara E Pavillet 1 collaboration

Chang Heon Lee 1 collaboration

Ana Miar 1 collaboration

Anjali Arora 1 collaboration

Karl J Morten 1 collaboration

Anne M Hendriks 1 collaboration

Elisabete Pires 1 collaboration

Dimitra Kalamida 1 collaboration

B Christoffer Lagerholm 1 collaboration

Rudolf S N Fehrmann 1 collaboration

Wilfred F A den Dunnen 1 collaboration

Andrei I Tarasov 1 collaboration

Otto Baba 1 collaboration

John Morris 1 collaboration

James S O McCullagh 1 collaboration

Mathilde Jalving 1 collaboration

Samuel B Bader 1 collaboration

Tiffany S Ma 1 collaboration

Charlotte J Simpson 1 collaboration

Jiachen Liang 1 collaboration

Sakura Eri B Maezono 1 collaboration

Monica M Olcina 1 collaboration

Ester M Hammond 1 collaboration

Sofia Zanotti 1 collaboration

Nicola Montemurro 1 collaboration

Gian Luca De Salvo 1 collaboration

Riccardo Soffietti 1 collaboration

Chiara Maria Mazzanti 1 collaboration

Tamara Ius 1 collaboration

Maria Caffo 1 collaboration

Guido Bocci 1 collaboration

Giuseppe Lombardi 1 collaboration

Andrea Tangherloni 1 collaboration

Simone G Riva 1 collaboration

Brynelle Myers 1 collaboration

Paolo Cazzaniga 1 collaboration

Nicholas Coupe 1 collaboration

Lina Guo 1 collaboration

Olivia Espinosa 1 collaboration

Richard Colling 1 collaboration

Andrea Marshall 1 collaboration

Ashwin Nandakumar 1 collaboration

Ruud van Stiphout 1 collaboration

Pippa G Corrie 1 collaboration

Mark R Middleton 1 collaboration

Valentine M Macaulay 1 collaboration

Alessandro Valli 1 collaboration

Matteo Morotti 1 collaboration

Patrick K Albers 1 collaboration

Tomoyoshi Soga 1 collaboration

Katharina Feldinger 1 collaboration

Roman Fischer 1 collaboration

Martin Frejno 1 collaboration

Alan McIntyre 1 collaboration

Dilair Baban 1 collaboration

Miguel Rodriguez 1 collaboration

Oscar Yanes 1 collaboration

Hannah J Whittington 1 collaboration

Hannah A Lake 1 collaboration

Sevasti Zervou 1 collaboration

Craig A Lygate 1 collaboration

Rebecca Carter 1 collaboration

Azadeh Cheraghchi-Bashi 1 collaboration

Adam Westhorpe 1 collaboration

Sheng Yu 1 collaboration

Yasmin Shanneik 1 collaboration

Elena Seraia 1 collaboration

Djamila Ouaret 1 collaboration

Yasuhiro Inoue 1 collaboration

Catherine Koch 1 collaboration

Jenny Wilding 1 collaboration

Daniel Ebner 1 collaboration

Anderson J Ryan 1 collaboration

Ricky A Sharma 1 collaboration

Simon R Lord 1 collaboration

Jennifer M Collins 1 collaboration

Edoardo Gaude 1 collaboration

Barbara A Fielding 1 collaboration

Katherine E Pinnick 1 collaboration

Ulrike Harjes 1 collaboration

Ashvina Segaran 1 collaboration

Pooja Jha 1 collaboration

Gerald Hoefler 1 collaboration

Michael N Pollak 1 collaboration

Alastair M Thompson 1 collaboration

Pankaj G Roy 1 collaboration

Ruth English 1 collaboration

Rosie F Adams 1 collaboration

Christian Frezza 1 collaboration

Fredrik Karpe 1 collaboration

Matteo Di Giovannantonio 1 collaboration

Benjamin Hl Harris 1 collaboration

Ping Zhang 1 collaboration

Isaac Kitchen-Smith 1 collaboration

Lingyun Xiong 1 collaboration

Natasha Sahgal 1 collaboration

Giovanni Stracquadanio 1 collaboration

Marsha Wallace 1 collaboration

Sarah Blagden 1 collaboration

Simon Lord 1 collaboration

David Harris 1 collaboration

Adrian H L Harris 1 collaboration

Gareth L Bond 1 collaboration

G P Ralli 1 collaboration

R D Carter 1 collaboration

D R McGowan 1 collaboration

W-C Cheng 1 collaboration

D Liu 1 collaboration

E J Teoh 1 collaboration

N Patel 1 collaboration

F Gleeson 1 collaboration

A L Harris 1 collaboration

S R Lord 1 collaboration

F M Buffa 1 collaboration

J D Fenwick 1 collaboration

Hugo J W L Aerts 1 collaboration

Milena Rizzo 1 collaboration

Sara Franceschi 1 collaboration

Francesca Lessi 1 collaboration

Charalampos P Triantafyllidis 1 collaboration

Fiona Hartley 1 collaboration

Ana Miar Cuervo 1 collaboration

Enio Gjerga 1 collaboration

Philip Charlton 1 collaboration

Linda van Bijsterveldt 1 collaboration

Julio Saez Rodriguez 1 collaboration

Jacob Scott 1 collaboration

Purnima Sundaresan 1 collaboration

Michael Veness 1 collaboration

Sandro Porceddu 1 collaboration

Eric Hau 1 collaboration

Harriet E Gee 1 collaboration

Kenneth Kahn 1 collaboration

Martin Hadley 1 collaboration

Rowan Wilson 1 collaboration

Michael Skwarski 1 collaboration

Daniel R McGowan 1 collaboration

Elizabeth Belcher 1 collaboration

Francesco Di Chiara 1 collaboration

Dionisios Stavroulias 1 collaboration

Mark McCole 1 collaboration

Jennifer L Derham 1 collaboration

Kwun-Ye Chu 1 collaboration

Eugene Teoh 1 collaboration

Jagat Chauhan 1 collaboration

Dawn O'Reilly 1 collaboration

Benjamin H L Harris 1 collaboration

Philip S Macklin 1 collaboration

Joshua A Bull 1 collaboration

Marcus Green 1 collaboration

Lisa K Folkes 1 collaboration

Petra Ferencz 1 collaboration

Paula L Croal 1 collaboration

Helen Flight 1 collaboration

Cathy Qi 1 collaboration

Jane Holmes 1 collaboration

James P B O'Connor 1 collaboration

Fergus V Gleeson 1 collaboration

W Gillies McKenna 1 collaboration

Daniel Bulte 1 collaboration

Ruth E Macpherson 1 collaboration

Jagat S Chauhan 1 collaboration

Michael Hölzel 1 collaboration

Jean-Philippe Lambert 1 collaboration

Colin R Goding 1 collaboration