Tim Maughan

Affiliations

Computational Biology and Integrative Genomics Lab, MRC/CRUK Oxford Institute and Department of Oncology, University of Oxford, Oxford, UK.

Publications (11)

Guidelines for using sigQC for systematic evaluation of gene signatures.

Nature protocols

Avec: Andrew Dhawan , Alessandro Barberis , Wei-Chen Cheng , Enric Domingo , Catharine West , Tim Maughan , Jacob G Scott , Adrian L Harris , Francesca M Buffa

Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancreatic cancer (SCALOP-2).

BMC cancer

Avec: Victoria Y Strauss , Rachel Shaw , Pradeep S Virdee , Christopher N Hurt , Elizabeth Ward , Bethan Tranter , Neel Patel , John Bridgewater , Philip Parsons , Ganesh Radhakrishna , Eric O'Neill , David Sebag-Montefiore , Maria Hawkins , Pippa G Corrie , Timothy Maughan , Somnath Mukherjee

Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.

The lancet. Gastroenterology & hepatology

Avec: Alex J Cornish , Philip J Law , Maria Timofeeva , Kimmo Palin , Susan M Farrington , Claire Palles , Mark A Jenkins , Graham Casey , Hermann Brenner , Jenny Chang-Claude , Michael Hoffmeister , Iva Kirac , Tim Maughan , Stefanie Brezina , Andrea Gsur , Jeremy P Cheadle , Lauri A Aaltonen , Ian Tomlinson , Malcolm G Dunlop , Richard S Houlston

Stereotactic Magnetic Resonance-Guided Daily Adaptive SABR (SMART) for Localised Non-Metastatic Pancreatic Cancer: First Reported Clinical Outcomes From the UK.

Clinical oncology (Royal College of Radiologists (Great Britain))

Avec: K Nugent , S Mukherjee , S Teoh , B George , A Martin , A Gaya , L Aznar-Garcia , K Chu , M Robinson , T Maughan , J Good

TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes.

Gastroenterology

Avec: Michael Eyres , Simone Lanfredini , Haonan Xu , Adam Burns , Andrew Blake , Frances Willenbrock , Robert Goldin , Daniel Hughes , Sophie Hughes , Asmita Thapa , Dimitris Vavoulis , Aline Hubert , Zenobia D'Costa , Ahmad Sabbagh , Aswin G Abraham , Christine Blancher , Stephanie Jones , Clare Verrill , Michael Silva , Zahir Soonawalla , Timothy Maughan , Anna Schuh , Somnath Mukherjee , Eric O'Neill

Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: a Mendelian randomisation analysis.

British journal of cancer

Avec: Richard Culliford , Alex J Cornish , Philip J Law , Susan M Farrington , Kimmo Palin , Mark A Jenkins , Graham Casey , Michael Hoffmeister , Hermann Brenner , Jenny Chang-Claude , Iva Kirac , Tim Maughan , Stefanie Brezina , Andrea Gsur , Jeremy P Cheadle , Lauri A Aaltonen , Malcom G Dunlop , Richard S Houlston

This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols.

Trials

Avec: Francesca Schiavone , Riya Bathia , Krishna Letchemanan , Lindsey Masters , Claire Amos , Anna Bara , Louise Brown , Clare Gilson , Cheryl Pugh , Nafisah Atako , Fleur Hudson , Mahesh Parmar , Ruth Langley , Richard S Kaplan , Chris Parker , Gert Attard , Noel W Clarke , Silke Gillessen , Nicholas D James , Tim Maughan , Matthew R Sydes , Auteur inconnu

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification.

Gut

Avec: Sam O Kleeman , Viktor H Koelzer , Helen Js Jones , Ester Gil Vazquez , Hayley Davis , James E East , Roland Arnold , Martijn Aj Koppens , Andrew Blake , Enric Domingo , Chris Cunningham , Andrew D Beggs , Valerie Pestinger , Maurice B Loughrey , Lai-Mun Wang , Tamsin Rm Lannagan , Susan L Woods , Daniel Worthley , S Cort Consortium , Ian Tomlinson , Philip D Dunne , Timothy Maughan , Simon J Leedham

A phase II open label, randomised study of ipilimumab with temozolomide versus temozolomide alone after surgery and chemoradiotherapy in patients with recently diagnosed glioblastoma: the Ipi-Glio trial protocol.

BMC cancer

Avec: Nicholas F Brown , Stasya M Ng , Claire Brooks , Tim Coutts , Jane Holmes , Corran Roberts , Leena Elhussein , Peter Hoskin , Tim Maughan , Sarah Blagden , Paul Mulholland

Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.

Gut

Avec: Shania M Corry , Amy Mb McCorry , Tamsin Rm Lannagan , Niamh A Leonard , Natalie C Fisher , Ryan M Byrne , Petros Tsantoulis , Xabier Cortes-Lavaud , Raheleh Amirkhah , Keara L Redmond , Aoife J McCooey , Sudhir B Malla , Emily Rogan , Svetlana Sakhnevych , Michael A Gillespie , Mark White , Susan D Richman , Rene-Filip Jackstadt , Andrew D Campbell , Sarah Maguire , Auteur inconnu , Simon S McDade , Daniel B Longley , Maurice B Loughrey , Helen G Coleman , Emma M Kerr , Sabine Tejpar , Timothy Maughan , Simon J Leedham , Donna M Small , Aideen E Ryan , Owen J Sansom , Mark Lawler , Philip D Dunne

Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Natalie C Fisher , Ryan M Byrne , Holly Leslie , Colin Wood , Assya Legrini , Andrew J Cameron , Baharak Ahmaderaghi , Shania M Corry , Sudhir B Malla , Raheleh Amirkhah , Aoife J McCooey , Emily Rogan , Keara L Redmond , Svetlana Sakhnevych , Enric Domingo , James Jackson , Maurice B Loughrey , Simon Leedham , Tim Maughan , Mark Lawler , Owen J Sansom , Felicity Lamrock , Viktor H Koelzer , Nigel B Jamieson , Philip D Dunne

Réseau de co-auteurs

Timothy Maughan 4 collaborations

Enric Domingo 3 collaborations

Maurice B Loughrey 3 collaborations

Philip D Dunne 3 collaborations

Eric O'Neill 2 collaborations

Somnath Mukherjee 2 collaborations

Alex J Cornish 2 collaborations

Philip J Law 2 collaborations

Kimmo Palin 2 collaborations

Susan M Farrington 2 collaborations

Mark A Jenkins 2 collaborations

Graham Casey 2 collaborations

Hermann Brenner 2 collaborations

Jenny Chang-Claude 2 collaborations

Michael Hoffmeister 2 collaborations

Iva Kirac 2 collaborations

Stefanie Brezina 2 collaborations

Andrea Gsur 2 collaborations

Jeremy P Cheadle 2 collaborations

Lauri A Aaltonen 2 collaborations

Ian Tomlinson 2 collaborations

Richard S Houlston 2 collaborations

Andrew Blake 2 collaborations

None None 2 collaborations

Viktor H Koelzer 2 collaborations

Tamsin Rm Lannagan 2 collaborations

Simon J Leedham 2 collaborations

Shania M Corry 2 collaborations

Natalie C Fisher 2 collaborations

Ryan M Byrne 2 collaborations

Raheleh Amirkhah 2 collaborations

Keara L Redmond 2 collaborations

Aoife J McCooey 2 collaborations

Sudhir B Malla 2 collaborations

Emily Rogan 2 collaborations

Svetlana Sakhnevych 2 collaborations

Owen J Sansom 2 collaborations

Mark Lawler 2 collaborations

Andrew Dhawan 1 collaboration

Alessandro Barberis 1 collaboration

Wei-Chen Cheng 1 collaboration

Catharine West 1 collaboration

Jacob G Scott 1 collaboration

Adrian L Harris 1 collaboration

Francesca M Buffa 1 collaboration

Victoria Y Strauss 1 collaboration

Rachel Shaw 1 collaboration

Pradeep S Virdee 1 collaboration

Christopher N Hurt 1 collaboration

Elizabeth Ward 1 collaboration

Bethan Tranter 1 collaboration

Neel Patel 1 collaboration

John Bridgewater 1 collaboration

Philip Parsons 1 collaboration

Ganesh Radhakrishna 1 collaboration

David Sebag-Montefiore 1 collaboration

Maria Hawkins 1 collaboration

Pippa G Corrie 1 collaboration

Maria Timofeeva 1 collaboration

Claire Palles 1 collaboration

Malcolm G Dunlop 1 collaboration

K Nugent 1 collaboration

S Mukherjee 1 collaboration

S Teoh 1 collaboration

B George 1 collaboration

A Martin 1 collaboration

A Gaya 1 collaboration

L Aznar-Garcia 1 collaboration

K Chu 1 collaboration

M Robinson 1 collaboration

T Maughan 1 collaboration

J Good 1 collaboration

Michael Eyres 1 collaboration

Simone Lanfredini 1 collaboration

Haonan Xu 1 collaboration

Adam Burns 1 collaboration

Frances Willenbrock 1 collaboration

Robert Goldin 1 collaboration

Daniel Hughes 1 collaboration

Sophie Hughes 1 collaboration

Asmita Thapa 1 collaboration

Dimitris Vavoulis 1 collaboration

Aline Hubert 1 collaboration

Zenobia D'Costa 1 collaboration

Ahmad Sabbagh 1 collaboration

Aswin G Abraham 1 collaboration

Christine Blancher 1 collaboration

Stephanie Jones 1 collaboration

Clare Verrill 1 collaboration

Michael Silva 1 collaboration

Zahir Soonawalla 1 collaboration

Anna Schuh 1 collaboration

Richard Culliford 1 collaboration

Malcom G Dunlop 1 collaboration

Francesca Schiavone 1 collaboration

Riya Bathia 1 collaboration

Krishna Letchemanan 1 collaboration

Lindsey Masters 1 collaboration

Claire Amos 1 collaboration

Anna Bara 1 collaboration

Louise Brown 1 collaboration

Clare Gilson 1 collaboration

Cheryl Pugh 1 collaboration

Nafisah Atako 1 collaboration

Fleur Hudson 1 collaboration

Mahesh Parmar 1 collaboration

Ruth Langley 1 collaboration

Richard S Kaplan 1 collaboration

Chris Parker 1 collaboration

Gert Attard 1 collaboration

Noel W Clarke 1 collaboration

Silke Gillessen 1 collaboration

Nicholas D James 1 collaboration

Matthew R Sydes 1 collaboration

Sam O Kleeman 1 collaboration

Helen Js Jones 1 collaboration

Ester Gil Vazquez 1 collaboration

Hayley Davis 1 collaboration

James E East 1 collaboration

Roland Arnold 1 collaboration

Martijn Aj Koppens 1 collaboration

Chris Cunningham 1 collaboration

Andrew D Beggs 1 collaboration

Valerie Pestinger 1 collaboration

Lai-Mun Wang 1 collaboration

Susan L Woods 1 collaboration

Daniel Worthley 1 collaboration

S Cort Consortium 1 collaboration

Nicholas F Brown 1 collaboration

Stasya M Ng 1 collaboration

Claire Brooks 1 collaboration

Tim Coutts 1 collaboration

Jane Holmes 1 collaboration

Corran Roberts 1 collaboration

Leena Elhussein 1 collaboration

Peter Hoskin 1 collaboration

Sarah Blagden 1 collaboration

Paul Mulholland 1 collaboration

Amy Mb McCorry 1 collaboration

Niamh A Leonard 1 collaboration

Petros Tsantoulis 1 collaboration

Xabier Cortes-Lavaud 1 collaboration

Michael A Gillespie 1 collaboration

Mark White 1 collaboration

Susan D Richman 1 collaboration

Rene-Filip Jackstadt 1 collaboration

Andrew D Campbell 1 collaboration

Sarah Maguire 1 collaboration

Simon S McDade 1 collaboration

Daniel B Longley 1 collaboration

Helen G Coleman 1 collaboration

Emma M Kerr 1 collaboration

Sabine Tejpar 1 collaboration

Donna M Small 1 collaboration

Aideen E Ryan 1 collaboration

Holly Leslie 1 collaboration

Colin Wood 1 collaboration

Assya Legrini 1 collaboration

Andrew J Cameron 1 collaboration

Baharak Ahmaderaghi 1 collaboration

James Jackson 1 collaboration

Simon Leedham 1 collaboration

Felicity Lamrock 1 collaboration

Nigel B Jamieson 1 collaboration