Chromosome Preference During Homologous Recombination Repair of DNA Double-Strand Breaks in
DSB repair
Drosophila melanogaster
homologous recombination
interhomolog recombination
intrachromosomal recombination
Journal
G3 (Bethesda, Md.)
ISSN: 2160-1836
Titre abrégé: G3 (Bethesda)
Pays: England
ID NLM: 101566598
Informations de publication
Date de publication:
05 11 2019
05 11 2019
Historique:
pubmed:
15
9
2019
medline:
11
4
2020
entrez:
15
9
2019
Statut:
epublish
Résumé
DNA double-strand breaks (DSBs) are especially toxic DNA lesions that, if left unrepaired, can lead to wide-ranging genomic instability. Of the pathways available to repair DSBs, the most accurate is homologous recombination (HR), where a homologous sequence is used as a donor template to restore genetic information at the break site. While much of the biochemical aspects of HR repair have been characterized, how the repair machinery locates and discriminates between potential homologous donor templates throughout the genome remains elusive. We use
Identifiants
pubmed: 31519746
pii: g3.119.400607
doi: 10.1534/g3.119.400607
pmc: PMC6829126
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3773-3780Subventions
Organisme : NIGMS NIH HHS
ID : R15 GM129628
Pays : United States
Informations de copyright
Copyright © 2019 Fernandez et al.
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