An imaging-based risk calculator for prediction of conversion to psychosis in clinical high-risk individuals using glutamate


Journal

Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207

Informations de publication

Date de publication:
12 2020
Historique:
received: 02 02 2019
revised: 04 09 2019
accepted: 06 09 2019
pubmed: 17 9 2019
medline: 22 6 2021
entrez: 17 9 2019
Statut: ppublish

Résumé

Risk calculators for prediction of conversion of Clinical High-Risk (CHR) individuals to syndromal psychosis have recently been developed and have generated considerable clinical use and research interest. Predictor variables in these calculators have been clinical rather than biological, and our goal was to incorporate a neurochemical imaging measure into this framework and assess its impact on prediction. We combined striatal glutamate

Identifiants

pubmed: 31522867
pii: S0920-9964(19)30413-X
doi: 10.1016/j.schres.2019.09.004
pmc: PMC7065933
mid: NIHMS1539879
pii:
doi:

Substances chimiques

Glutamic Acid 3KX376GY7L

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

70-73

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH110270
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

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Auteurs

Lawrence S Kegeles (LS)

Columbia University, Department of Psychiatry, New York State Psychiatric Institute (NYSPI), New York, NY, USA.

Adam Ciarleglio (A)

George Washington University, Milken Institute School of Public Health, Department of Epidemiology and Biostatistics, Washington, DC, USA.

Pablo León-Ortiz (P)

Laboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.

Francisco Reyes-Madrigal (F)

Laboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.

Jeffrey A Lieberman (JA)

Columbia University, Department of Psychiatry, New York State Psychiatric Institute (NYSPI), New York, NY, USA.

Gary Brucato (G)

Columbia University, Department of Psychiatry, New York State Psychiatric Institute (NYSPI), New York, NY, USA.

Ragy R Girgis (RR)

Columbia University, Department of Psychiatry, New York State Psychiatric Institute (NYSPI), New York, NY, USA.

Camilo de la Fuente-Sandoval (C)

Laboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico. Electronic address: fcamilo@unam.mx.

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Classifications MeSH