Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition.
electrophysiology
fatigue
functional magnetic resonance imaging
human
motor slowing
neuroscience
repetitive movements
transcranial magnetic stimulation
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
16 09 2019
16 09 2019
Historique:
received:
11
03
2019
accepted:
22
08
2019
entrez:
17
9
2019
pubmed:
17
9
2019
medline:
8
2
2020
Statut:
epublish
Résumé
Motor fatigability emerges when demanding tasks are executed over an extended period of time. Here, we used repetitive low-force movements that cause a gradual reduction in movement speed (or 'motor slowing') to study the central component of fatigability in healthy adults. We show that motor slowing is associated with a gradual increase of net excitability in the motor network and, specifically, in primary motor cortex (M1), which results from overall disinhibition. Importantly, we link performance decrements to a breakdown of surround inhibition in M1, which is associated with high coactivation of antagonistic muscle groups. This is consistent with the model that a loss of inhibitory control might broaden the tuning of population vectors such that movement patterns become more variable, ill-timed and effortful. We propose that the release of inhibition in M1 is an important mechanism underpinning motor fatigability and, potentially, also pathological fatigue as frequently observed in patients with brain disorders.
Identifiants
pubmed: 31524600
doi: 10.7554/eLife.46750
pii: 46750
pmc: PMC6746551
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Swiss National Science Foundation
ID : SNSF 320030_175616
Pays : Switzerland
Informations de copyright
© 2019, Bächinger et al.
Déclaration de conflit d'intérêts
MB, RL, FT, SH, JB, NW No competing interests declared
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