Serial brain MRI changes related to autoimmune pathophysiology in Hashimoto encephalopathy with anti-NAE antibodies: A case-series study.
Anti-NH(2)-terminal of α-enolase autoantibodies
Hashimoto encephalopathy
MRI
Journal
Journal of the neurological sciences
ISSN: 1878-5883
Titre abrégé: J Neurol Sci
Pays: Netherlands
ID NLM: 0375403
Informations de publication
Date de publication:
15 Nov 2019
15 Nov 2019
Historique:
received:
07
06
2019
revised:
03
09
2019
accepted:
06
09
2019
pubmed:
17
9
2019
medline:
15
9
2020
entrez:
17
9
2019
Statut:
ppublish
Résumé
Hashimoto encephalopathy (HE) is an autoimmune-mediated encephalopathy associated with anti-thyroid antibodies. We previously discovered serum autoantibodies against the NH We investigated serial brain MR images in 12 Japanese patients with HE who had serum anti-NAE antibodies. Brain MRI showed diffuse white matter abnormalities and/or multiple small subcortical lesions in 10 patients. These lesions were apparently non-specific; however, in 7 of these patients we observed expanding and diminishing white matter lesions, emerging subcortical high-intensity spots on diffusion-weighted images, or reversible limbic lesions, which worsened at relapse and improved after recovery following immunotherapies. MRI lesions that fluctuate according to the disease condition were frequently observed in HE patients with anti-NAE antibodies, which suggests that these fluctuation may be associated with the autoimmune pathophysiology of HE.
Identifiants
pubmed: 31525528
pii: S0022-510X(19)30385-5
doi: 10.1016/j.jns.2019.116453
pii:
doi:
Substances chimiques
Autoantibodies
0
Biomarkers
0
Phosphopyruvate Hydratase
EC 4.2.1.11
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116453Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.