Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na

Amides / chemistry Animals Central Nervous System / metabolism Dogs Epilepsy / drug therapy Hep G2 Cells Humans Madin Darby Canine Kidney Cells Mice Models, Molecular NAV1.6 Voltage-Gated Sodium Channel / chemistry Protein Domains Protein Isoforms / antagonists & inhibitors Sodium Channel Blockers / chemistry Structure-Activity Relationship

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
14 11 2019
Historique:
pubmed: 19 9 2019
medline: 17 6 2020
entrez: 19 9 2019
Statut: ppublish

Résumé

Nonselective antagonists of voltage-gated sodium (Na

Identifiants

DOI: 10.1021/acs.jmedchem.9b01032 PMID: 31525968
pubmed: 31525968
doi: 10.1021/acs.jmedchem.9b01032
doi:

Substances chimiques

Amides 0
NAV1.6 Voltage-Gated Sodium Channel 0
Protein Isoforms 0
Scn8a protein, mouse 0
Sodium Channel Blockers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9618-9641

Auteurs

Thilo Focken (T)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
ORCID: 0000-0003-1993-2476

Kristen Burford (K)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Michael E Grimwood (ME)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Alla Zenova (A)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Jean-Christophe Andrez (JC)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Wei Gong (W)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Michael Wilson (M)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Matt Taron (M)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Shannon Decker (S)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Verner Lofstrand (V)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Sultan Chowdhury (S)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Noah Shuart (N)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Sophia Lin (S)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Samuel J Goodchild (SJ)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Clint Young (C)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Maegan Soriano (M)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Parisa K Tari (PK)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Matthew Waldbrook (M)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Karen Nelkenbrecher (K)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Rainbow Kwan (R)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Andrea Lindgren (A)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Gina de Boer (G)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Stephanie Lee (S)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Luis Sojo (L)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Robert J DeVita (RJ)

RJD Medicinal Chemistry and Drug Discovery Consulting LLC , Westfield , New Jersey 07090 , United States.

Charles J Cohen (CJ)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Steven S Wesolowski (SS)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

J P Johnson (JP)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Christoph M Dehnhardt (CM)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
ORCID: 0000-0001-5213-6354

James R Empfield (JR)

Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amides › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Eucaryotes › Animaux › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Système nerveux › Système nerveux central › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules rénales canines Madin-Darby › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.6 › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Bloqueurs de canaux sodiques › Identification of CNS-Penetrant Aryl...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Identification of CNS-Penetrant Aryl...