Infrapatellar fat pad abnormalities are associated with a higher inflammatory synovial fluid cytokine profile in young adults following ACL tear.

Adipose Tissue / diagnostic imaging Adult Anterior Cruciate Ligament Injuries / metabolism Anterior Cruciate Ligament Reconstruction Cytokines / analysis Female Humans Knee / diagnostic imaging Magnetic Resonance Imaging Male Synovial Fluid / chemistry Synovitis / diagnostic imaging
Anterior cruciate ligament tear Cartilage damage Inflammation Magnetic resonance imaging Matrix metalloproteinases Post-traumatic osteoarthritis (PTOA) T1ρ relaxation time T2 relaxation time

Journal

Osteoarthritis and cartilage
ISSN: 1522-9653
Titre abrégé: Osteoarthritis Cartilage
Pays: England
ID NLM: 9305697

Informations de publication

Date de publication:
01 2020
Historique:
received: 28 11 2018
revised: 08 08 2019
accepted: 03 09 2019
pubmed: 19 9 2019
medline: 7 2 2021
entrez: 19 9 2019
Statut: ppublish

Résumé

To evaluate the degree of knee fat pad abnormalities after acute anterior cruciate ligament (ACL) tear via magnetic resonance fat pad scoring and to assess cross-sectionally its association with synovial fluid biomarkers and with early cartilage damage as quantified via T1ρ and T2 relaxation time measurements. 26 patients with acute ACL tears underwent 3T MR scanning of the injured knee prior to ACL reconstruction. The presence and degree of abnormalities of the infrapatellar (IPFP) and the suprapatellar (SPFP) fat pads were scored on MR images along with grading of effusion-synovitis and synovial proliferations. Knee cartilage composition was assessed by 3T MR T1ρ and T2 mapping in six knee compartments. We quantified concentrations of 20 biomarkers in synovial fluid aspirated at the time of ACL reconstruction. Spearman rank partial correlations with adjustments for age and gender were employed to evaluate correlations of MR, particularly cartilage composition and fat pad abnormalities, and biomarker data. The degree of IPFP abnormality correlated positively with the synovial levels of the inflammatory cytokine markers IFN-γ (ρ This exploratory study suggests that acute ACL rupture can be associated with damage to knee tissues such as the inferior fat pad of the knee. Such fat pad injury could be partially responsible for the apparent post-injury pro-inflammatory response noted in ACL-injured individuals. However, future longitudinal studies are needed to link ACL-rupture associated fat pad injury with important patient outcomes such as the development of posttraumatic osteoarthritis.

Identifiants

DOI: 10.1016/j.joca.2019.09.001 PMID: 31526878 PMC: PMC6935420
pubmed: 31526878
pii: S1063-4584(19)31206-3
doi: 10.1016/j.joca.2019.09.001
pmc: PMC6935420
mid: NIHMS1542328
pii:
doi:

Substances chimiques

Cytokines 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

82-91

Subventions

Organisme : NICHD NIH HHS
ID : K12 HD051958
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR066262
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR075055
Pays : United States
Organisme : NIAMS NIH HHS
ID : P50 AR060752
Pays : United States

Informations de copyright

Copyright © 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

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Auteurs

U Heilmeier (U)

Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, University of California San Francisco, San Francisco, CA, USA. Electronic address: ursula.heilmeier@ucsf.edu.

K Mamoto (K)

Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, University of California San Francisco, San Francisco, CA, USA; Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Orthopaedic Surgery, Osaka City University Medical School, Osaka, Japan. Electronic address: mamoto7@hotmail.com.

K Amano (K)

Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, University of California San Francisco, San Francisco, CA, USA. Electronic address: amanokeiko@gmail.com.

B Eck (B)

Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA. Electronic address: eckb@ccf.org.

M Tanaka (M)

Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, University of California San Francisco, San Francisco, CA, USA. Electronic address: matthew.tanaka@ucsf.edu.

J A Bullen (JA)

Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. Electronic address: bullenj@ccf.org.

B J Schwaiger (BJ)

Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, University of California San Francisco, San Francisco, CA, USA. Electronic address: benedikt.schwaiger@tum.de.

J L Huebner (JL)

Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. Electronic address: janet.huebner@duke.edu.

T V Stabler (TV)

Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. Electronic address: stablert@hotmail.com.

V B Kraus (VB)

Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. Electronic address: kraus004@duke.edu.

C B Ma (CB)

Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA. Electronic address: maben@ucsf.edu.

T M Link (TM)

Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, University of California San Francisco, San Francisco, CA, USA. Electronic address: thomas.link@ucsf.edu.

X Li (X)

Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, University of California San Francisco, San Francisco, CA, USA; Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA. Electronic address: lix6@ccf.org.

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Infrapatellar fat pad abnormalities are...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Infrapatellar fat pad abnormalities are...
questionsmedicales.fr › Plaies et blessures › Traumatismes de la jambe › Traumatismes du genou › Lésions du ligament croisé antérieur › Infrapatellar fat pad abnormalities are...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie reconstructive › Arthroplastie › Reconstruction du ligament croisé antérieur › Infrapatellar fat pad abnormalities are...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Infrapatellar fat pad abnormalities are...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Infrapatellar fat pad abnormalities are...
questionsmedicales.fr › Régions du corps › Membres › Membre inférieur › Genou › Infrapatellar fat pad abnormalities are...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Infrapatellar fat pad abnormalities are...
questionsmedicales.fr › Liquides et sécrétions biologiques › Liquides biologiques › Liquide extracellulaire › Synovie › Infrapatellar fat pad abnormalities are...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies articulaires › Synovite › Infrapatellar fat pad abnormalities are...