Obesity-associated mutant melanocortin-4 receptors with normal Gα
Adaptor Proteins, Signal Transducing
/ pharmacology
Animals
CHO Cells
Cells, Cultured
Cricetulus
Dose-Response Relationship, Drug
GTP-Binding Protein alpha Subunits
/ metabolism
Glycosylation
Humans
Mutation
Obesity
/ genetics
Receptor, Melanocortin, Type 4
/ metabolism
alpha-MSH
/ pharmacology
beta-Arrestins
/ metabolism
POMC
receptors; membrane/nuclear
α-MSH
Journal
Journal of neuroendocrinology
ISSN: 1365-2826
Titre abrégé: J Neuroendocrinol
Pays: United States
ID NLM: 8913461
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
07
05
2019
revised:
11
08
2019
accepted:
10
09
2019
pubmed:
19
9
2019
medline:
15
12
2020
entrez:
19
9
2019
Statut:
ppublish
Résumé
Mutations in the melanocortin-4 receptor (MC4R) are the most common cause of early syndromic obesity known. Most of these mutations result in a loss of protein expression, α-melanocyte-stimulating hormone binding, receptor trafficking or coupling to the stimulatory G-protein, Gα
Substances chimiques
Adaptor Proteins, Signal Transducing
0
GTP-Binding Protein alpha Subunits
0
MC4R protein, human
0
MRAP2 protein, human
0
Receptor, Melanocortin, Type 4
0
beta-Arrestins
0
alpha-MSH
581-05-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12795Subventions
Organisme : NIDDK NIH HHS
ID : F31 DK107253
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK070332
Pays : United States
Organisme : NIDDK NIH HHS
ID : RO1 DK070332
Pays : United States
Informations de copyright
© 2019 British Society for Neuroendocrinology.
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