Titre : Récepteur de la mélanocortine de type 4

Récepteur de la mélanocortine de type 4 : Questions médicales fréquentes

Nom anglais: Receptor, Melanocortin, Type 4

Descriptor UI: D044105

Tree Number: D12.776.543.750.750.660.285.500.937

Questions fréquentes et termes MeSH associés

Général 1

#1

Erreur lors de la génération.

Veuillez réessayer ultérieurement.
Receptor, Melanocortin, Type 4
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale

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Auteurs principaux

Ya-Xiong Tao

13 publications dans cette catégorie

Affiliations :
  • Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Publications dans "Récepteur de la mélanocortine de type 4" : Voir toutes les publications (13)

Peter Kühnen

7 publications dans cette catégorie

Affiliations :
  • Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin und Humboldt-Universität zu Berlin, Institute for Experimental Pediatric Endocrinology, Augustenburger Platz 1, 13353 Berlin, Germany.
Publications dans "Récepteur de la mélanocortine de type 4" : Voir toutes les publications (7)

Patrick Scheerer

7 publications dans cette catégorie

Affiliations :
  • Group Protein X-ray Crystallography and Signal Transduction, Institute of Medical Physics and Biophysics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-10117 Berlin, Germany.
Publications dans "Récepteur de la mélanocortine de type 4" : Voir toutes les publications (7)

Heike Biebermann

6 publications dans cette catégorie

Affiliations :
  • Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin und Humboldt-Universität zu Berlin, Institute for Experimental Pediatric Endocrinology, Augustenburger Platz 1, 13353 Berlin, Germany.
Publications dans "Récepteur de la mélanocortine de type 4" : Voir toutes les publications (6)

Ren-Lei Ji

6 publications dans cette catégorie

Affiliations :
  • Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Publications dans "Récepteur de la mélanocortine de type 4" : Voir toutes les publications (6)

Gunnar Kleinau

6 publications dans cette catégorie

Affiliations :
  • Group Protein X-ray Crystallography and Signal Transduction, Institute of Medical Physics and Biophysics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-10117 Berlin, Germany.
Publications dans "Récepteur de la mélanocortine de type 4" : Voir toutes les publications (6)

Chao Zhang

5 publications dans cette catégorie

Affiliations :
  • Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China. Electronic address: zhangchao@tongji.edu.cn.
Publications dans "Récepteur de la mélanocortine de type 4" :

Heiko Krude

5 publications dans cette catégorie

Affiliations :
  • Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin und Humboldt-Universität zu Berlin, Institute for Experimental Pediatric Endocrinology, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address: heiko.krude@charite.de.
Publications dans "Récepteur de la mélanocortine de type 4" :

Ting Liu

3 publications dans cette catégorie

Affiliations :
  • Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Publications dans "Récepteur de la mélanocortine de type 4" :

Hai-Shen Wen

3 publications dans cette catégorie

Affiliations :
  • The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, China.
Publications dans "Récepteur de la mélanocortine de type 4" :

Lei Li

3 publications dans cette catégorie

Affiliations :
  • Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Publications dans "Récepteur de la mélanocortine de type 4" :

Savannah Y Williams

3 publications dans cette catégorie

Affiliations :
  • Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Publications dans "Récepteur de la mélanocortine de type 4" :

Roger D Cone

3 publications dans cette catégorie

Affiliations :
  • Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. rcone@umich.edu stevens@shanghaitech.edu.cn.
  • Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Publications dans "Récepteur de la mélanocortine de type 4" :

Rihan Hai

3 publications dans cette catégorie

Affiliations :
  • Vocational and Technical College, Inner Mongolia Agricultural University, Baotou 014109, China.
Publications dans "Récepteur de la mélanocortine de type 4" :

Chenguang Du

3 publications dans cette catégorie

Affiliations :
  • College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
  • Vocational and Technical College, Inner Mongolia Agricultural University, Baotou 014109, China.
  • Inner Mongolia Key Laboratory of Basic Veterinary Science, Hohhot 010018, China.
Publications dans "Récepteur de la mélanocortine de type 4" :

Sarah Paisdzior

3 publications dans cette catégorie

Affiliations :
  • Institute of Experimental Pediatric Endocrinology, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Publications dans "Récepteur de la mélanocortine de type 4" :

Ming Zhu

2 publications dans cette catégorie

Affiliations :
  • Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Publications dans "Récepteur de la mélanocortine de type 4" :

Bingxin Xu

2 publications dans cette catégorie

Affiliations :
  • Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Publications dans "Récepteur de la mélanocortine de type 4" :

Zhi-Shuai Hou

2 publications dans cette catégorie

Affiliations :
  • Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States.
Publications dans "Récepteur de la mélanocortine de type 4" :

Yun Li

2 publications dans cette catégorie

Affiliations :
  • The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, China.
Publications dans "Récepteur de la mélanocortine de type 4" :

Sources (10000 au total)

Novel melanocortin-3 and -4 receptor functional variants in Asian children with severe obesity.

11 Oct 2023
DOI: 10.1210/clinem/dgad602 PMID: 37820740

This study aims to identify and functionally characterize Melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R) variants in an Asian cohort of children with severe early-onset obesity.... Whole exome sequencing was performed to screen for MC3R and MC4R coding variants in 488 Asian children with early-onset severe obesity (BMI for age ≥ 97th percentile). Functionality of the identified ... Four MC3R and two MC4R heterozygous non-synonymous rare variants were detected. There were 3 novel variants: MC3R c.151G > C (p.Val51Leu), MC4R c.127C > A (p.Gln43Lys) and MC4R c.272T > G (p.Met91Arg)... Our functional assays demonstrated that MC3R c.127G > A (p.Glu43Lys) and MC4R c.272T > G (p.Met91Arg) variants might be predisposing to early-onset obesity and further studies are needed to establish ...

Efficacy and Safety of Setmelanotide, a Melanocortin-4 Receptor Agonist, for Obese Patients: A Systematic Review and Meta-Analysis.

04 Oct 2023
DOI: 10.3390/jpm13101460 PMID: 37888071

A malfunction in the melanocortin-4 receptor (MC4R) is associated with obesity in rare genetic syndromes; setmelanotide is a new drug that activates this receptor and is being used to treat severe obe... We searched PubMed, Embase, and Cochrane for randomized and nonrandomized clinical trials using setmelanotide. We considered a... We included 376 patients, of whom 328 (87.2%) received setmelanotide for a mean follow-up of 52 weeks. The mean age was 32.8 (14.67) years. Weight loss was significant (MD -3.52; 95% CI -3.98, -3.05;... Our results support the use of setmelanotide in treating severe obesity....