Structural Complexity and Plasticity of Signaling Regulation at the Melanocortin-4 Receptor.
Agouti-Related Protein
/ chemistry
Amino Acid Sequence
Animals
Arrestins
/ metabolism
Binding Sites
Humans
Ligands
Loss of Function Mutation
Obesity
/ genetics
Protein Binding
Protein Conformation
Receptor Activity-Modifying Proteins
/ chemistry
Receptor, Melanocortin, Type 4
/ antagonists & inhibitors
Signal Transduction
/ genetics
alpha-MSH
/ chemistry
G protein-coupled receptor
melanocortin receptors
melanocortin-4 receptor
signal transduction
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Aug 2020
10 Aug 2020
Historique:
received:
12
07
2020
revised:
03
08
2020
accepted:
06
08
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
9
3
2021
Statut:
epublish
Résumé
The melanocortin-4 receptor (MC4R) is a class A G protein-coupled receptor (GPCR), essential for regulation of appetite and metabolism. Pathogenic inactivating
Identifiants
pubmed: 32785054
pii: ijms21165728
doi: 10.3390/ijms21165728
pmc: PMC7460885
pii:
doi:
Substances chimiques
Agouti-Related Protein
0
Arrestins
0
Ligands
0
Receptor Activity-Modifying Proteins
0
Receptor, Melanocortin, Type 4
0
alpha-MSH
581-05-5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : CRC 1423, project number 421152132, subprojects A01,A05, Z03
Organisme : Deutsche Forschungsgemeinschaft
ID : CRC 1365, project number 394046635, subproject A03
Organisme : Deutsche Forschungsgemeinschaft
ID : Germany´s Excellence Strategies -EXC 2008/1 (UniSysCat) - 390540038
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