Pharmacological modulation of dual melanocortin-4 receptor signaling by melanocortin receptor accessory proteins in the Xenopus laevis.
Adaptor Proteins, Signal Transducing
/ metabolism
Animals
Appetite Regulation
/ physiology
Carrier Proteins
/ metabolism
Cell Membrane
/ metabolism
Homeostasis
/ physiology
Melanocortins
/ metabolism
Receptor, Melanocortin, Type 4
/ genetics
Receptors, Melanocortin
/ metabolism
Signal Transduction
/ physiology
Xenopus laevis
/ metabolism
MC4R
MRAP
MRAP2
Xenopus laevis
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
29
12
2020
received:
06
10
2020
accepted:
04
01
2021
pubmed:
28
1
2021
medline:
21
10
2021
entrez:
27
1
2021
Statut:
ppublish
Résumé
Physiological modulation of melanocortin-4 receptor (MC4R) signaling by MRAP2 proteins plays an indispensable role in appetite control and energy homeostasis in the central nervous system. Great interspecies differences of the interaction and regulation of melanocortin receptors by MRAP protein family have been reported in several diploid vertebrates but never been investigated in the tetrapod amphibian Xenopus laevis. Here, we performed phylogenetic and synteny-based analyses to explore the evolutionary aspects of dual copies of X. laevis MC4R (xlMC4R) and MRAP2 (xlMRAP2) proteins. Our data showed that xlMRAPs directly interacted with xlMC4Rs on the cell surface as a functional antiparallel dimeric topology and pharmacological studies suggested a homology specific regulatory pattern of the melanocortin system in X. laevis.
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Carrier Proteins
0
Melanocortins
0
Receptor, Melanocortin, Type 4
0
Receptors, Melanocortin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5980-5993Informations de copyright
© 2021 Wiley Periodicals LLC.
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