Determination of the melanocortin-4 receptor structure identifies Ca
Calcium
/ chemistry
Crystallography, X-Ray
Cyclic AMP
/ chemistry
Humans
Ligands
Melanocyte-Stimulating Hormones
/ chemistry
Mutation
Potassium Channels, Inwardly Rectifying
/ chemistry
Protein Binding
Protein Multimerization
Protein Structure, Secondary
Receptor, Melanocortin, Type 4
/ antagonists & inhibitors
Receptors, G-Protein-Coupled
/ antagonists & inhibitors
Signal Transduction
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
24 04 2020
24 04 2020
Historique:
received:
21
10
2019
accepted:
09
03
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
15
5
2020
Statut:
ppublish
Résumé
The melanocortin-4 receptor (MC4R) is involved in energy homeostasis and is an important drug target for syndromic obesity. We report the structure of the antagonist SHU9119-bound human MC4R at 2.8-angstrom resolution. Ca
Identifiants
pubmed: 32327598
pii: 368/6489/428
doi: 10.1126/science.aaz8995
pmc: PMC7567314
mid: NIHMS1636576
doi:
Substances chimiques
Kir7.1 channel
0
Ligands
0
Potassium Channels, Inwardly Rectifying
0
Receptor, Melanocortin, Type 4
0
Receptors, G-Protein-Coupled
0
SHU 9119
168482-23-3
Melanocyte-Stimulating Hormones
9002-79-3
Cyclic AMP
E0399OZS9N
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
428-433Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK110403
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK070332
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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