Peripheral actions and direct central-local communications of melanocortin 4 receptor signaling.
Body weight
Energy homeostasis
GPCR
Melanocortin-4 receptor
Journal
Journal of sport and health science
ISSN: 2213-2961
Titre abrégé: J Sport Health Sci
Pays: China
ID NLM: 101606001
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
29
06
2020
revised:
25
09
2020
accepted:
20
10
2020
pubmed:
24
2
2021
medline:
14
2
2023
entrez:
23
2
2021
Statut:
ppublish
Résumé
Melanocortin 4 receptor (MC4R), the most important monogenetic cause of human metabolic disorders, has been of great interest to many researchers in the field of energy homeostasis and public health. Because MC4R is a vital pharmaceutical target for maintaining controllable appetite and body weight for professional athletes, previous studies have mainly focused on the central, rather than the peripheral, roles of MC4R. Thus, the local expression of MC4R and its behavioral regulation remain unclear. In an attempt to shed light on different directions for future studies of MC4R signaling, we review a series of recent and important studies exploring the peripheral functions of MC4R and the direct physiological interaction between peripheral organs and central MC4R neurons in this article.
Identifiants
pubmed: 33621697
pii: S2095-2546(21)00021-1
doi: 10.1016/j.jshs.2021.02.001
pmc: PMC9923399
pii:
doi:
Substances chimiques
Receptor, Melanocortin, Type 4
0
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
45-51Informations de copyright
Copyright © 2021. Production and hosting by Elsevier B.V.
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