Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults.
Calcium
Gastric inhibitory polypeptide
Incretins
Metabolism
Peptide tyrosine tyrosine
Postprandial
Protein
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
26
02
2019
accepted:
11
09
2019
pubmed:
19
9
2019
medline:
26
5
2021
entrez:
19
9
2019
Statut:
ppublish
Résumé
To examine whether calcium type and co-ingestion with protein alter gut hormone availability. Healthy adults aged 26 ± 7 years (mean ± SD) completed three randomized, double-blind, crossover studies. In all studies, arterialized blood was sampled postprandially over 120 min to determine GLP-1, GIP and PYY responses, alongside appetite ratings, energy expenditure and blood pressure. In study 1 (n = 20), three treatments matched for total calcium content (1058 mg) were compared: calcium citrate (CALCITR); milk minerals rich in calcium (MILK MINERALS); and milk minerals rich in calcium plus co-ingestion of 50 g whey protein hydrolysate (MILK MINERALS + PROTEIN). In study 2 (n = 6), 50 g whey protein hydrolysate (PROTEIN) was compared to MILK MINERALS + PROTEIN. In study 3 (n = 6), MILK MINERALS was compared to the vehicle of ingestion (water plus sucralose; CONTROL). MILK MINERALS + PROTEIN increased GLP-1 incremental area under the curve (iAUC) by ~ ninefold (43.7 ± 11.1 pmol L When ingested alone, milk minerals rich in calcium do not increase GLP-1 secretion compared to calcium citrate. Co-ingesting high-dose whey protein hydrolysate with milk minerals rich in calcium increases postprandial GLP-1 concentrations to some of the highest physiological levels ever reported. Registered at ClinicalTrials.gov: NCT03232034, NCT03370484, NCT03370497.
Identifiants
pubmed: 31531707
doi: 10.1007/s00394-019-02092-4
pii: 10.1007/s00394-019-02092-4
pmc: PMC7413905
doi:
Substances chimiques
Minerals
0
Protein Hydrolysates
0
Whey Proteins
0
Glucagon-Like Peptide 1
89750-14-1
Calcium
SY7Q814VUP
Banques de données
ClinicalTrials.gov
['NCT03232034', 'NCT03370497', 'NCT03370484']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
2449-2462Références
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