TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions.

Aged Aged, 80 and over CD8-Positive T-Lymphocytes / immunology Caco-2 Cells Cytokines / immunology Female Humans Inflammation / immunology Lymphocyte Activation Male Middle Aged Mucosal-Associated Invariant T Cells / immunology Receptors, Antigen, T-Cell / immunology Signal Transduction / immunology THP-1 Cells
MAIT cells TCR signaling cytokines effector functions tissue repair

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
17 09 2019
Historique:
received: 08 12 2018
revised: 17 04 2019
accepted: 15 08 2019
entrez: 19 9 2019
pubmed: 19 9 2019
medline: 12 9 2020
Statut: ppublish

Résumé

MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examined the impact of combinations of TCR-dependent and TCR-independent signals in human CD8

Identifiants

DOI: 10.1016/j.celrep.2019.08.050 PMID: 31533032 PMC: PMC6899450
pubmed: 31533032
pii: S2211-1247(19)31098-8
doi: 10.1016/j.celrep.2019.08.050
pmc: PMC6899450
pii:
doi:

Substances chimiques

Cytokines 0
Receptors, Antigen, T-Cell 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3077-3091.e5

Subventions

Organisme : Wellcome Trust
ID : 109965/Z/15/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 211050/Z/18/Z
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

Références

J Immunol. 2007 Apr 1;178(7):4615-22
pubmed: 17372020
Nature. 2018 Mar 29;555(7698):594-595
pubmed: 29595806
Am J Pathol. 2018 Nov;188(11):2446-2456
pubmed: 30142332
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Eur J Immunol. 2015 Aug;45(8):2286-98
pubmed: 26046663
Nat Commun. 2018 Aug 22;9(1):3350
pubmed: 30135490
Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10133-8
pubmed: 27543331
Int Immunol. 2000 Feb;12(2):151-60
pubmed: 10653850
Immunol Cell Biol. 2019 Jul;97(6):538-551
pubmed: 30695101
Nat Immunol. 2018 Jul;19(7):755-765
pubmed: 29915298
Nature. 2008 Sep 11;455(7210):246-50
pubmed: 18701887
Immunity. 2002 Mar;16(3):479-92
pubmed: 11911831
J Immunol. 2013 Nov 15;191(10):5268-77
pubmed: 24108697
Mucosal Immunol. 2013 Sep;6(5):886-99
pubmed: 23250276
Clin Immunol. 2004 Jul;112(1):66-77
pubmed: 15207783
Nat Immunol. 2018 Dec;19(12):1403-1414
pubmed: 30397350
Biostatistics. 2007 Jan;8(1):118-27
pubmed: 16632515
Science. 2019 Jan 4;363(6422):
pubmed: 30523076
Mucosal Immunol. 2016 Mar;9(2):401-13
pubmed: 26220166
Immunity. 2008 Jul 18;29(1):79-89
pubmed: 18571443
J Exp Med. 2013 Oct 21;210(11):2305-20
pubmed: 24101382
Eur J Immunol. 2019 Jan;49(1):133-143
pubmed: 30372518
Cell. 2018 Feb 8;172(4):784-796.e18
pubmed: 29358051
Mucosal Immunol. 2017 Jan;10(1):35-45
pubmed: 27049062
J Immunol. 2000 Aug 15;165(4):1933-8
pubmed: 10925275
Nat Immunol. 2017 Dec;18(12):1321-1331
pubmed: 28991267
J Clin Invest. 2018 May 1;128(5):1919-1936
pubmed: 29629900
Nat Commun. 2018 Nov 9;9(1):4706
pubmed: 30413689
Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3006-11
pubmed: 20133607
Mucosal Immunol. 2017 Jan;10(1):58-68
pubmed: 27143301
J Immunol. 2003 Nov 1;171(9):4868-74
pubmed: 14568967
Nat Med. 2017 May;23(5):579-589
pubmed: 28368383
Front Immunol. 2019 Mar 06;10:197
pubmed: 30894851
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nat Rev Immunol. 2014 Dec;14(12):783-95
pubmed: 25421700
Mucosal Immunol. 2015 May;8(3):545-58
pubmed: 25269704
J Exp Med. 2011 Jun 6;208(6):1127-33
pubmed: 21576383
Nature. 2012 Nov 29;491(7426):717-23
pubmed: 23051753
Nat Commun. 2016 Jun 23;7:11653
pubmed: 27337592
Blood. 2011 Sep 8;118(10):2752-62
pubmed: 21791427
JCI Insight. 2016 Jun 2;1(8):null
pubmed: 27331143
Cytometry A. 2009 Apr;75(4):362-70
pubmed: 19006067
Eur J Immunol. 2014 Jan;44(1):195-203
pubmed: 24019201
Front Immunol. 2017 Aug 30;8:1031
pubmed: 28912775
Cell Rep. 2019 Sep 17;28(12):3061-3076.e5
pubmed: 31533031
Eur J Microbiol Immunol (Bp). 2011 Mar;1(1):70-79
pubmed: 22348196
Cell Rep. 2014 Nov 6;9(3):1075-88
pubmed: 25437561
J Exp Med. 2015 Jun 29;212(7):1095-108
pubmed: 26101265
Nat Immunol. 2008 Oct;9(10):1091-4
pubmed: 18800157
Nat Commun. 2016 Apr 21;7:11394
pubmed: 27099134
Nat Commun. 2017 Mar 08;8:14599
pubmed: 28272391
Blood. 2009 Feb 26;113(9):1948-56
pubmed: 19104082
Front Immunol. 2014 Oct 08;5:450
pubmed: 25339949
J Biol Chem. 2011 Aug 19;286(33):28889-901
pubmed: 21693707
Eur J Immunol. 2009 Nov;39(11):3239-50
pubmed: 19839006
Nat Immunol. 2015 Nov;16(11):1114-23
pubmed: 26482978
Clin Exp Immunol. 2014 May;176(2):266-74
pubmed: 24450998
Mucosal Immunol. 2015 Mar;8(2):429-40
pubmed: 25269706
J Clin Invest. 1998 Apr 15;101(8):1693-8
pubmed: 9541500
Cell Rep. 2019 Sep 17;28(12):3249-3262.e5
pubmed: 31533045
Blood. 2011 Jan 27;117(4):1250-9
pubmed: 21084709

Auteurs

Tianqi Leng (T)

Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK.

Hossain Delowar Akther (HD)

Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

Carl-Philipp Hackstein (CP)

Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

Kate Powell (K)

Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Department of Microbiology and Immunology, University of Otago, Otago, New Zealand.

Thomas King (T)

Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK.

Matthias Friedrich (M)

The Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK.

Zoe Christoforidou (Z)

Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

Sarah McCuaig (S)

The Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK.

Mastura Neyazi (M)

The Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK.

Carolina V Arancibia-Cárcamo (CV)

Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

Joachim Hagel (J)

Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK.

Fiona Powrie (F)

The Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK.
Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

Raphael Sanches Peres (RS)

The Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK.

Val Millar (V)

Target Discovery Institute, Roosevelt Dr., Oxford OX3 7FZ, UK.

Daniel Ebner (D)

Target Discovery Institute, Roosevelt Dr., Oxford OX3 7FZ, UK.

Rajesh Lamichhane (R)

Department of Microbiology and Immunology, University of Otago, Otago, New Zealand.

James Ussher (J)

Department of Microbiology and Immunology, University of Otago, Otago, New Zealand.

Timothy S C Hinks (TSC)

NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK; Respiratory Medicine Unit, Nuffield Department of Medicine Experimental Medicine, University of Oxford, Oxford OX3 9DU, UK; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.

Emanuele Marchi (E)

Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK.

Chris Willberg (C)

Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK.

Paul Klenerman (P)

Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK; NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address: paul.klenerman@medawar.ox.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › TCR and Inflammatory Signals Tune Human MAIT...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › TCR and Inflammatory Signals Tune Human MAIT...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › TCR and Inflammatory Signals Tune Human MAIT...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › TCR and Inflammatory Signals Tune Human MAIT...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › TCR and Inflammatory Signals Tune Human MAIT...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › TCR and Inflammatory Signals Tune Human MAIT...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › TCR and Inflammatory Signals Tune Human MAIT...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › TCR and Inflammatory Signals Tune Human MAIT...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › TCR and Inflammatory Signals Tune Human MAIT...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Cellules T invariantes associées aux muqueuses › TCR and Inflammatory Signals Tune Human MAIT...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › TCR and Inflammatory Signals Tune Human MAIT...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › TCR and Inflammatory Signals Tune Human MAIT...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cellules THP-1 › TCR and Inflammatory Signals Tune Human MAIT...