Invadopodia-mediated ECM degradation is enhanced in the G1 phase of the cell cycle.
Cell cycle
FUCCI
G1
Intravital imaging
Invadopodia
Invasion
Journal
Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457
Informations de publication
Date de publication:
18 10 2019
18 10 2019
Historique:
received:
25
10
2018
accepted:
10
09
2019
pubmed:
20
9
2019
medline:
16
7
2020
entrez:
20
9
2019
Statut:
epublish
Résumé
The process of tumor cell invasion and metastasis includes assembly of invadopodia, protrusions capable of degrading the extracellular matrix (ECM). The effect of cell cycle progression on invadopodia has not been elucidated. In this study, by using invadopodia and cell cycle fluorescent markers, we show in 2D and 3D cultures, as well as
Identifiants
pubmed: 31533971
pii: jcs.227116
doi: 10.1242/jcs.227116
pmc: PMC6826011
pii:
doi:
Substances chimiques
Cdkn1b protein, mouse
0
Fish protein, mouse
0
Mmp14 protein, mouse
0
Phosphate-Binding Proteins
0
Cyclin-Dependent Kinase Inhibitor p27
147604-94-2
Matrix Metalloproteinase 14
EC 3.4.24.80
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R03 CA216134
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA172360
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM121679
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA230777
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117437
Pays : United States
Informations de copyright
© 2019. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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