Protein surface topography as a tool to enhance the selective activity of a potassium channel blocker.
Amino Acid Sequence
Animals
Humans
Kv1.3 Potassium Channel
/ chemistry
Ligands
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Dynamics Simulation
Mutation
Peptides
/ chemistry
Potassium Channel Blockers
/ chemistry
Protein Binding
Protein Conformation
Proteins
/ chemistry
Surface Properties
alpha-hairpinin
hefutoxin
ion channel
molecular dynamics
neurotoxin
nuclear magnetic resonance (NMR)
peptides
pore blocker
potassium channel
protein motif
protein structure
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
29 11 2019
29 11 2019
Historique:
received:
05
08
2019
pubmed:
20
9
2019
medline:
23
6
2020
entrez:
20
9
2019
Statut:
ppublish
Résumé
Tk-hefu is an artificial peptide designed based on the α-hairpinin scaffold, which selectively blocks voltage-gated potassium channels K
Identifiants
pubmed: 31533989
pii: S0021-9258(20)30697-9
doi: 10.1074/jbc.RA119.010494
pmc: PMC6885618
pii:
doi:
Substances chimiques
Kv1.3 Potassium Channel
0
Ligands
0
Peptides
0
Potassium Channel Blockers
0
Proteins
0
Banques de données
PDB
['5LM0', '2M6A', '3LUT', '4JTA']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18349-18359Informations de copyright
© 2019 Berkut et al.
Références
J Comput Chem. 2005 Dec;26(16):1701-18
pubmed: 16211538
J Biol Chem. 2011 Jul 15;286(28):25145-53
pubmed: 21561864
Comput Struct Biotechnol J. 2013 Apr 02;5:e201302011
pubmed: 24688704
Proteins. 2018 Oct;86(10):1117-1122
pubmed: 30007037
Cold Spring Harb Perspect Med. 2016 May 02;6(5):
pubmed: 27141079
Annu Rev Biophys Biomol Struct. 2000;29:291-325
pubmed: 10940251
Curr Protoc Mol Biol. 2001 May;Chapter 16:Unit16.8
pubmed: 18265135
Immunol Rev. 2009 Sep;231(1):59-87
pubmed: 19754890
Database (Oxford). 2016 Apr 17;2016:
pubmed: 27087309
J Chem Inf Model. 2014 Apr 28;54(4):1189-99
pubmed: 24689707
J Biol Chem. 2002 Aug 16;277(33):30040-7
pubmed: 12034709
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 03;369(1638):20130094
pubmed: 24493742
Elife. 2013 May 21;2:e00594
pubmed: 23705070
Nat Rev Drug Discov. 2017 Jan;16(1):19-34
pubmed: 27910877
Neuron. 1994 Jun;12(6):1377-88
pubmed: 7516689
Nat Rev Drug Discov. 2013 Dec;12(12):948-62
pubmed: 24287782
Annu Rev Immunol. 2015;33:291-353
pubmed: 25861976
Protein Expr Purif. 2003 Sep;31(1):133-9
pubmed: 12963350
Channels (Austin). 2015;9(6):367-75
pubmed: 26556400
J Biol Chem. 2015 Sep 25;290(39):23616-30
pubmed: 26242733
Biochemistry (Mosc). 2015 Dec;80(13):1764-99
pubmed: 26878580
Curr Opin Chem Biol. 2017 Jun;38:97-107
pubmed: 28412597
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11352-7
pubmed: 20534430
J Biomol NMR. 1992 Nov;2(6):661-5
pubmed: 1490109
J Biol Chem. 1997 Feb 14;272(7):4302-9
pubmed: 9020148
Transl Stroke Res. 2014 Feb;5(1):38-58
pubmed: 24323720
Biochem J. 2012 Aug 15;446(1):69-77
pubmed: 22612157
Toxicon. 2015 Jan;93:125-35
pubmed: 25432067
Annu Rev Physiol. 2015;77:475-9
pubmed: 25668025
Sci Rep. 2016 Sep 09;6:33112
pubmed: 27612191
Biochem J. 2008 May 1;411(3):687-96
pubmed: 18215128
FEBS J. 2013 Aug;280(15):3594-608
pubmed: 23702306
J Biol Chem. 2001 Nov 16;276(46):43145-51
pubmed: 11527975
Nat Rev Neurol. 2016 Apr;12(4):195-203
pubmed: 26943780
J Biol Chem. 2009 Jul 31;284(31):20684-91
pubmed: 19509294
J Biomol NMR. 1997 Oct;10(3):301-6
pubmed: 20700833
J Biomol NMR. 1998 Feb;11(2):221-6
pubmed: 9679296
Protein Sci. 2016 Jul;25(7):1168-78
pubmed: 26808055
J Biol Chem. 2013 Jun 28;288(26):19014-27
pubmed: 23637230
J Gen Physiol. 2008 May;131(5):399-405
pubmed: 18411331
Nat Biotechnol. 2017 Feb;35(2):108-112
pubmed: 28135234
J Biol Chem. 1998 Sep 25;273(39):25393-403
pubmed: 9738007
J Biomol NMR. 2002 Nov;24(3):171-89
pubmed: 12522306
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17414-9
pubmed: 17088564
J Biol Chem. 2014 May 16;289(20):14331-40
pubmed: 24671422
Nature. 1974 Apr 26;248(5451):769-71
pubmed: 4599082