Effect modifiers of lung function and daily air pollutant variability in a panel of schoolchildren.
Air Pollutants
/ analysis
Air Pollution
/ adverse effects
Animals
Asthma
/ physiopathology
Bronchoconstrictor Agents
/ pharmacology
Child
Female
Forced Expiratory Volume
Humans
Lung
/ drug effects
Male
Methacholine Chloride
/ pharmacology
Nitrogen Dioxide
/ analysis
Nitrogen Oxides
/ analysis
Particulate Matter
/ analysis
Schools
Severity of Illness Index
South Africa
Spirometry
Sulfur Dioxide
/ analysis
Time Factors
asthma epidemiology
paediatric asthma
Journal
Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
22
12
2017
revised:
19
08
2019
accepted:
20
08
2019
pubmed:
20
9
2019
medline:
19
5
2020
entrez:
20
9
2019
Statut:
ppublish
Résumé
Acute pollutant-related lung function changes among children varies across pollutants and lag periods. We examined whether short-term air pollutant fluctuations were related to daily lung function among a panel of children and whether these effects are modified by airway hyperresponsiveness, location and asthma severity. Students from randomly selected grade 4 classrooms at seven primary schools in Durban, participated, together with asthmatic children from grades 3-6 (n=423). The schools were from high pollutant exposed communities (south) and compared with schools from communities with lower levels of pollution (north), with similar socioeconomic profiles. Interviews, spirometry and methacholine challenge testing were conducted. Bihourly lung function measurements were performed over a 3-week period in four phases. During all schooldays, students blew into their personal digital monitors every 1.5-2 hours. Nitrogen dioxide (NO FEV This first panel study in sub-Saharan Africa, showed significant declines in lung function, in response to NO and NO
Sections du résumé
BACKGROUND
Acute pollutant-related lung function changes among children varies across pollutants and lag periods. We examined whether short-term air pollutant fluctuations were related to daily lung function among a panel of children and whether these effects are modified by airway hyperresponsiveness, location and asthma severity.
METHODS
Students from randomly selected grade 4 classrooms at seven primary schools in Durban, participated, together with asthmatic children from grades 3-6 (n=423). The schools were from high pollutant exposed communities (south) and compared with schools from communities with lower levels of pollution (north), with similar socioeconomic profiles. Interviews, spirometry and methacholine challenge testing were conducted. Bihourly lung function measurements were performed over a 3-week period in four phases. During all schooldays, students blew into their personal digital monitors every 1.5-2 hours. Nitrogen dioxide (NO
RESULTS
FEV
CONCLUSIONS
This first panel study in sub-Saharan Africa, showed significant declines in lung function, in response to NO and NO
Identifiants
pubmed: 31534032
pii: thoraxjnl-2017-211458
doi: 10.1136/thoraxjnl-2017-211458
doi:
Substances chimiques
Air Pollutants
0
Bronchoconstrictor Agents
0
Nitrogen Oxides
0
Particulate Matter
0
Sulfur Dioxide
0UZA3422Q4
Methacholine Chloride
0W5ETF9M2K
Nitrogen Dioxide
S7G510RUBH
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1055-1062Subventions
Organisme : FIC NIH HHS
ID : D43 TW000812
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.