Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Heart-Explant Derived Cell Dysfunction.

Animals Antioxidants / metabolism Cell- and Tissue-Based Therapy Chronic Disease Diabetes Complications Extracellular Vesicles / metabolism Heart Failure / enzymology Humans Hyperglycemia / complications Lactoylglutathione Lyase / genetics Mice Mice, Inbred C57BL Mice, Transgenic Myocardial Infarction / enzymology Oxidative Stress Reactive Oxygen Species / metabolism
cardiac stem cells diabetes extracellular vesicles heart failure hyperglycemia myocardial infarction oxidative stress reactive dicarbonyls

Journal

Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395

Informations de publication

Date de publication:
2019
Historique:
received: 13 05 2019
accepted: 06 07 2019
entrez: 20 9 2019
pubmed: 20 9 2019
medline: 19 8 2020
Statut: epublish

Résumé

Decades of work have shown that diabetes increases the risk of heart disease and worsens clinical outcomes after myocardial infarction. Because diabetes is an absolute contraindication to heart transplant, cell therapy is increasingly being explored as a means of improving heart function for these patients with very few other options. Given that hyperglycemia promotes the generation of toxic metabolites, the influence of the key detoxification enzyme glyoxalase 1 (Glo1) on chronic hyperglycemia induced heart explant-derived cell (EDC) dysfunction was investigated.

Identifiants

DOI: 10.7150/thno.36639 PMID: 31534514 PMC: PMC6735395
pubmed: 31534514
doi: 10.7150/thno.36639
pii: thnov09p5720
pmc: PMC6735395
doi:

Substances chimiques

Antioxidants 0
Reactive Oxygen Species 0
GLO1 protein, human EC 4.4.1.5
Lactoylglutathione Lyase EC 4.4.1.5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5720-5730

Subventions

Organisme : CIHR
ID : FDN143278
Pays : Canada
Organisme : CIHR
ID : MC2-121291
Pays : Canada

Déclaration de conflit d'intérêts

Competing Interests: The authors have declared that no competing interest exists.

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Auteurs

Melanie Villanueva (M)

University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, Ottawa, Canada K1Y4W7.

Connor Michie (C)

University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, Ottawa, Canada K1Y4W7.

Sandrine Parent (S)

University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, Ottawa, Canada K1Y4W7.

Georges N Kanaan (GN)

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada K1H8M5.

Ghazaleh Rafatian (G)

University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, Ottawa, Canada K1Y4W7.

Pushpinder Kanda (P)

University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, Ottawa, Canada K1Y4W7.

Bin Ye (B)

University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, Ottawa, Canada K1Y4W7.

Wenbin Liang (W)

University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, Ottawa, Canada K1Y4W7.
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada K1H8M5.

Mary-Ellen Harper (ME)

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada K1H8M5.

Darryl R Davis (DR)

University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, Ottawa, Canada K1Y4W7.
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada K1H8M5.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Thérapeutique › Biothérapie › Thérapie cellulaire et tissulaire › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Complications du diabète › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Défaillance cardiaque › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hyperglycémie › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-sulfur lyases › Lactoyl glutathione lyase › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Glyoxalase 1 Prevents Chronic Hyperglycemia...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Glyoxalase 1 Prevents Chronic Hyperglycemia...