Genetic Factors in Mammalian Prion Diseases.

Animals Cattle Disease Models, Animal Genetic Association Studies Genetic Predisposition to Disease Genetic Testing Goats / genetics Humans Mammals / genetics Mice Polymorphism, Genetic Prion Diseases / etiology Prion Proteins / genetics Selection, Genetic Sheep / genetics

Creutzfeldt-Jakob disease genome-wide association study inherited prion disease prion protein prion protein gene quantitative trait locus

Journal

Annual review of genetics

ISSN: 1545-2948

Titre abrégé: Annu Rev Genet

Pays: United States

ID NLM: 0117605

Informations de publication

Date de publication:
03 12 2019

Historique:

pubmed: 21 9 2019

medline: 25 4 2020

entrez: 21 9 2019

Statut: ppublish

Résumé

Mammalian prion diseases are a group of neurodegenerative conditions caused by infection of the central nervous system with proteinaceous agents called prions, including sporadic, variant, and iatrogenic Creutzfeldt-Jakob disease; kuru; inherited prion disease; sheep scrapie; bovine spongiform encephalopathy; and chronic wasting disease. Prions are composed of misfolded and multimeric forms of the normal cellular prion protein (PrP). Prion diseases require host expression of the prion protein gene (

Identifiants

DOI: 10.1146/annurev-genet-120213-092352 PMID: 31537104

pubmed: 31537104

doi: 10.1146/annurev-genet-120213-092352

doi:

Substances chimiques

PRNP protein, human 0

Prion Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng