Genome-Wide Association Study on the Early-Phase Insulin Response to a Liquid Mixed Meal: Results From the NEO Study.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
12
04
2019
accepted:
09
09
2019
pubmed:
21
9
2019
medline:
17
3
2020
entrez:
21
9
2019
Statut:
ppublish
Résumé
Early-phase insulin secretion is a determinant of postprandial glucose homeostasis. In this study, we aimed to identify novel genetic variants associated with the early-phase insulin response to a liquid mixed meal by a genome-wide association study using a discovery and replication design embedded in the Netherlands Epidemiology of Obesity (NEO) study. The early-phase insulin response was defined as the difference between the natural logarithm-transformed insulin concentrations of the postprandial state at 30 min after a meal challenge and the fasting state (Δinsulin). After Bonferroni correction, rs505922 (β: -6.5% [minor allele frequency (MAF) 0.32,
Identifiants
pubmed: 31537524
pii: db19-0378
doi: 10.2337/db19-0378
doi:
Substances chimiques
ABO Blood-Group System
0
Blood Glucose
0
Insulin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2327-2336Informations de copyright
© 2019 by the American Diabetes Association.