Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action.
Animals
Brain-Derived Neurotrophic Factor
/ metabolism
Cyclic AMP Response Element-Binding Protein
/ metabolism
Depression
/ drug therapy
Dipterocarpaceae
/ chemistry
Ethanol
/ chemistry
Hypothalamo-Hypophyseal System
/ metabolism
Immediate-Early Proteins
/ biosynthesis
Male
Mice
Mice, Inbred ICR
Pituitary-Adrenal System
/ metabolism
Plant Extracts
/ chemistry
Plant Leaves
/ chemistry
Protein Serine-Threonine Kinases
/ biosynthesis
Stress, Psychological
/ drug therapy
Dipterocarpus alatus
HPA axis
MAO-A inhibition
UCMS
depression
flavonoids
neurogenesis
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
18 Sep 2019
18 Sep 2019
Historique:
received:
30
08
2019
revised:
11
09
2019
accepted:
17
09
2019
entrez:
22
9
2019
pubmed:
22
9
2019
medline:
6
2
2020
Statut:
epublish
Résumé
Treatment of the unpredictable chronic mild stress (UCMS) mice with the ethanol extract of Dipterocarpus alatus leaf attenuated anhedonia (increased sucrose preference) and behavioral despair (decreased immobility time in tail suspension test (TST) and forced swimming test (FST)). The extract not only decreased the elevation of serum corticosterone level and the index of over-activation of the hypothalamic-pituitary-adrenal (HPA) axis, caused by UCMS, but also ameliorated UCMS-induced up-regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) mRNA expression and down-regulation of cyclic AMP-responsive element binding (CREB) and brain-derived neurotrophic factor (BDNF) mRNAs in frontal cortex and hippocampus. In vitro monoamine oxidase (MAO) inhibition assays showed that the extract exhibited the partial selective inhibition on MAO-A. HPLC analysis of the extract showed the presence of flavonoids (luteolin-7-O-glucoside, kaempferol-3-glucoside, rutin) and phenolic acids (gallic acid, ferulic acid, and caffeic acid) as major constituents.
Identifiants
pubmed: 31540539
pii: molecules24183396
doi: 10.3390/molecules24183396
pmc: PMC6767234
pii:
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Creb1 protein, mouse
0
Cyclic AMP Response Element-Binding Protein
0
Immediate-Early Proteins
0
Plant Extracts
0
Ethanol
3K9958V90M
Protein Serine-Threonine Kinases
EC 2.7.11.1
serum-glucocorticoid regulated kinase
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Council of Thailand
ID : KKU-YN2560-015 and KKU-YN2561-006
Organisme : Fundação para a Ciência e Tecnologia
ID : UID/Multi/04423/2019
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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