Time elapsed between Zika and dengue virus infections affects antibody and T cell responses.
Animals
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
Cell Line
Cross Reactions
/ immunology
Cytokines
/ metabolism
Dengue
/ immunology
Dengue Virus
/ immunology
Host-Pathogen Interactions
/ immunology
Humans
Immunity
Immunity, Cellular
Macaca mulatta
/ immunology
Male
T-Lymphocytes
/ immunology
Time Factors
Viremia
Zika Virus
/ immunology
Zika Virus Infection
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 09 2019
20 09 2019
Historique:
received:
24
04
2019
accepted:
03
09
2019
entrez:
22
9
2019
pubmed:
22
9
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.
Identifiants
pubmed: 31541110
doi: 10.1038/s41467-019-12295-2
pii: 10.1038/s41467-019-12295-2
pmc: PMC6754404
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4316Subventions
Organisme : NIH HHS
ID : P40 OD012217
Pays : United States
Organisme : NIH HHS
ID : U42 OD011128
Pays : United States
Références
Sci Rep. 2017 Sep 5;7(1):10498
pubmed: 28874759
Trop Med Int Health. 2019 Apr;24(4):442-453
pubmed: 30624838
PLoS Pathog. 2019 Jan 24;15(1):e1007474
pubmed: 30677097
Lancet Glob Health. 2018 Feb;6(2):e140-e141
pubmed: 29389533
Am J Trop Med Hyg. 1988 Mar;38(2):411-9
pubmed: 3354774
Viruses. 2011 Dec;3(12):2374-95
pubmed: 22355444
J Immunol Methods. 2005 Jun;301(1-2):89-101
pubmed: 15896800
Rev Panam Salud Publica. 2002 Apr;11(4):223-7
pubmed: 12049030
JCI Insight. 2017 Apr 20;2(8):
pubmed: 28422757
Science. 2016 Aug 19;353(6301):823-6
pubmed: 27417494
J Virol. 2017 Nov 30;91(24):
pubmed: 28978707
N Engl J Med. 2016 Mar 10;374(10):951-8
pubmed: 26862926
Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):728-33
pubmed: 26729879
Emerg Infect Dis. 2017 May;23(5):773-781
pubmed: 28418292
J Infect Dis. 2018 Jul 13;218(4):536-545
pubmed: 29618091
Arch Virol. 2013 Jul;158(7):1445-59
pubmed: 23471635
J Am Assoc Lab Anim Sci. 2016 Mar;55(2):147-51
pubmed: 27025804
Clin Infect Dis. 2017 Oct 15;65(8):1260-1265
pubmed: 29017246
Nature. 2016 Aug 4;536(7614):48-53
pubmed: 27338953
Nature. 2016 Jul 25;535(7613):475-6
pubmed: 27466104
Nat Microbiol. 2017 Mar 13;2:17036
pubmed: 28288094
PLoS Negl Trop Dis. 2011 Jun;5(6):e1188
pubmed: 21713020
J Infect Public Health. 2014 Nov-Dec;7(6):489-95
pubmed: 24999118
Nat Med. 2016 Dec;22(12):1448-1455
pubmed: 27694931
Nature. 2013 Apr 25;496(7446):504-7
pubmed: 23563266
Front Immunol. 2014 Sep 24;5:452
pubmed: 25309540
PLoS Pathog. 2017 Aug 3;13(8):e1006487
pubmed: 28771605
Nature. 2017 Jun 15;546(7658):411-415
pubmed: 28538734
Curr Opin Virol. 2018 Apr;29:51-61
pubmed: 29597086
BMC Public Health. 2015 Mar 14;15:250
pubmed: 25886528
J Immunol. 2017 Aug 1;199(3):1003-1011
pubmed: 28667164
PLoS Negl Trop Dis. 2013 Aug 08;7(8):e2357
pubmed: 23951377
Nat Immunol. 2016 Sep;17(9):1102-8
pubmed: 27339099
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7852-7
pubmed: 27354515
Emerg Infect Dis. 2019 Feb;25(2):346-348
pubmed: 30666939
Emerg Microbes Infect. 2018 Jul 13;7(1):130
pubmed: 30006514
J Immunol. 2018 Dec 15;201(12):3487-3491
pubmed: 30413672
Lancet Glob Health. 2018 May;6(5):e494
pubmed: 29653619
Cell Stem Cell. 2016 Nov 3;19(5):672
pubmed: 27814481
J Infect Dis. 2016 Nov 1;214(9):1357-1360
pubmed: 27521359
PLoS One. 2011 Apr 29;6(4):e19323
pubmed: 21559444
PLoS Med. 2019 Jan 22;16(1):e1002726
pubmed: 30668565
J Infect Dis. 2014 Feb 1;209(3):360-8
pubmed: 23964110
Front Microbiol. 2013 Oct 11;4:305
pubmed: 24130557
Methods Mol Biol. 2015;1343:65-80
pubmed: 26420709
Front Cell Infect Microbiol. 2017 Jul 12;7:317
pubmed: 28748176
Nat Commun. 2017 Jun 23;8:15674
pubmed: 28643775
Lancet Glob Health. 2018 May;6(5):e495
pubmed: 29653620
Nat Commun. 2017 Nov 13;8(1):1459
pubmed: 29129917
Lancet. 2017 Aug 26;390(10097):861-870
pubmed: 28647172
Microbes Infect. 2007 Jul;9(8):940-6
pubmed: 17544804
Cell Rep. 2016 Aug 9;16(6):1485-1491
pubmed: 27481466
PLoS Pathog. 2019 Aug 1;15(8):e1007766
pubmed: 31369649
PLoS Negl Trop Dis. 2018 Oct 1;12(10):e0006540
pubmed: 30273352
Science. 2017 Apr 14;356(6334):175-180
pubmed: 28360135
J Virol. 2013 Mar;87(6):3409-24
pubmed: 23302884
J Virol. 2014 Nov;88(21):12438-51
pubmed: 25122792
mBio. 2016 Jul 19;7(4):
pubmed: 27435464
Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4256-63
pubmed: 26195744
Science. 2015 Sep 18;349(6254):1338-43
pubmed: 26383952
Vaccine. 2011 May 17;29(22):3895-904
pubmed: 21443963
Cell Host Microbe. 2018 Nov 14;24(5):743-750.e5
pubmed: 30439343
Immunity. 2008 May;28(5):710-22
pubmed: 18468462
Sci Rep. 2018 Nov 6;8(1):16435
pubmed: 30401870
PLoS One. 2018 Apr 25;13(4):e0196311
pubmed: 29694440