The association between plasma proneurotensin and glucose regulation is modified by country of birth.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 09 2019
20 09 2019
Historique:
received:
24
10
2018
accepted:
05
09
2019
entrez:
22
9
2019
pubmed:
22
9
2019
medline:
29
10
2020
Statut:
epublish
Résumé
The prevalence of type 2 diabetes (T2D) has increased dramatically in Middle Eastern populations that represent the largest non-European immigrant group in Sweden today. As proneurotensin predicts T2D, the aim of this study was to investigate differences in proneurotensin levels across populations of Middle Eastern and Caucasian origin and to study its associations with indices of glucose regulation. Participants in the age 30 to 75 years, living in Malmö, Sweden, and born in Iraq or Sweden, were recruited from the census register. Anthropometrics and fasting samples were collected and oral glucose tolerance tests conducted assessing insulin secretion (DIo) as well as insulin sensitivity (ISI). A total of 2155 individuals participated in the study, 1398 were Iraqi-born and 757 were Swedish-born participants. Higher fasting proneurotensin levels were observed in Iraqi- compared to Swedish-born participants (137.5 vs. 119.8 pmol/L; p < 0.001) data adjusted for age, sex and body mass index. In Iraqi participants only, plasma proneurotensin was associated with impaired glucose regulation assessed as ISI, DIo and HbA
Identifiants
pubmed: 31541150
doi: 10.1038/s41598-019-50040-3
pii: 10.1038/s41598-019-50040-3
pmc: PMC6754414
doi:
Substances chimiques
Protein Precursors
0
proneurotensin
0
Neurotensin
39379-15-2
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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