DAPK1 (death associated protein kinase 1) mediates mTORC1 activation and antiviral activities in CD8
Animals
Antiviral Agents
/ pharmacology
Arenaviridae Infections
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Cell Differentiation
Death-Associated Protein Kinases
/ physiology
Lymphocyte Activation
Lymphocytic choriomeningitis virus
/ drug effects
Mechanistic Target of Rapamycin Complex 1
/ genetics
Mice
Mice, Inbred C57BL
Mice, Knockout
Phosphatidylinositol 3-Kinases
/ genetics
Phosphorylation
Signal Transduction
TOR Serine-Threonine Kinases
/ genetics
antiviral function
mTORC1; CD8+ T cells
Journal
Cellular & molecular immunology
ISSN: 2042-0226
Titre abrégé: Cell Mol Immunol
Pays: China
ID NLM: 101242872
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
25
08
2019
accepted:
27
08
2019
pubmed:
22
9
2019
medline:
28
12
2021
entrez:
22
9
2019
Statut:
ppublish
Résumé
Mechanistic target of rapamycin complex 1 (mTORC1) regulates CD8
Identifiants
pubmed: 31541182
doi: 10.1038/s41423-019-0293-2
pii: 10.1038/s41423-019-0293-2
pmc: PMC7852660
doi:
Substances chimiques
Antiviral Agents
0
mTOR protein, mouse
EC 2.7.1.1
Dapk1 protein, mouse
EC 2.7.11.1
Death-Associated Protein Kinases
EC 2.7.11.1
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
138-149Références
Chi, H. Regulation and function of mTOR signalling in T cell fate decisions. Nat. Rev. Immunol. 12, 325–338 (2012).
pubmed: 22517423
pmcid: 3417069
Powell, J. D., Pollizzi, K. N., Heikamp, E. B. & Horton, M. R. Regulation of immune responses by mTOR. Annu. Rev. Immunol. 30, 39–68 (2012).
pubmed: 22136167
Saxton, R. A. & Sabatini, D. M. mTOR Signaling in growth, metabolism, and disease. Cell 169, 361–371 (2017).
pubmed: 28388417
Delgoffe, G. M., Kole, T. P., Zheng, Y., Zarek, P. E., Matthews, K. L. & Xiao, B. et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30, 832–844 (2009).
pubmed: 19538929
pmcid: 2768135
Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J. & Horton, M. R. et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 12, 295–303 (2011).
pubmed: 21358638
pmcid: 3077821
Xu, L., Huang, Q., Wang, H., Hao, Y., Bai, Q. & Hu, J. et al. The kinase mTORC1 promotes the generation and suppressive function of follicular regulatory T cells. Immunity 47, 538–551 (2017).
pubmed: 28930662
Zeng, H., Yang, K., Cloer, C., Neale, G., Vogel, P. & Chi, H. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature 499, 485–490 (2013).
pubmed: 23812589
pmcid: 3759242
Zeng, H., Cohen, S., Guy, C., Shrestha, S., Neale, G. & Brown, S. A. et al. mTORC1 and mTORC2 kinase signaling and glucose metabolism drive follicular helper T cell differentiation. Immunity 45, 540–554 (2016).
pubmed: 27637146
pmcid: 5050556
Ray, J. P., Staron, M. M., Shyer, J. A., Ho, P. C., Marshall, H. D. & Gray, S. M. et al. The interleukin-2-mTORc1 kinase axis defines the signaling, differentiation, and metabolism of T helper 1 and follicular B helper T cells. Immunity 43, 690–702 (2015).
pubmed: 26410627
pmcid: 4618086
Rao, R. R., Li, Q., Odunsi, K. & Shrikant, P. A. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and eomesodermin. Immunity 32, 67–78 (2010).
pubmed: 20060330
pmcid: 5836496
Pollizzi, K. N., Sun, I. H., Patel, C. H., Lo, Y. C., Oh, M. H. & Waickman, A. T. et al. Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation. Nat. Immunol. 17, 704–711 (2016).
pubmed: 27064374
pmcid: 4873361
Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A. & Bachmann, M. F. et al. mTOR regulates memory CD8 T-cell differentiation. Nature 460, 108–112 (2009).
pubmed: 19543266
pmcid: 2710807
Li, Q., Rao, R. R., Araki, K., Pollizzi, K., Odunsi, K. & Powell, J. D. et al. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity 34, 541–553 (2011).
pubmed: 21511183
pmcid: 3083826
Sowell, R. T., Rogozinska, M., Nelson, C. E., Vezys, V. & Marzo, A. L. Cutting edge: generation of effector cells that localize to mucosal tissues and form resident memory CD8 T cells is controlled by mTOR. J. Immunol. 193, 2067–2071 (2014).
pubmed: 25070853
pmcid: 4134982
Pollizzi, K. N., Patel, C. H., Sun, I. H., Oh, M. H., Waickman, A. T. & Wen, J. et al. mTORC1 and mTORC2 selectively regulate CD8(+) T cell differentiation. J. Clin. Investig. 125, 2090–2108 (2015).
pubmed: 25893604
Zhang, J., Kim, J., Alexander, A., Cai, S., Tripathi, D. N. & Dere, R. et al. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat. Cell Biol. 15, 1186–1196 (2013).
pubmed: 23955302
pmcid: 3789865
Yang, K., Shrestha, S., Zeng, H., Karmaus, P. W., Neale, G. & Vogel, P. et al. T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. Immunity 39, 1043–1056 (2013).
pubmed: 24315998
pmcid: 3986063
Kaech, S. M. & Cui, W. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat. Rev. Immunol. 12, 749–761 (2012).
pubmed: 23080391
pmcid: 4137483
Boyman, O. & Sprent, J. The role of interleukin-2 during homeostasis and activation of the immune system. Nat. Rev. Immunol. 12, 180–190 (2012).
pubmed: 22343569
Liao, W., Lin, J. X. & Leonard, W. J. Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity 38, 13–25 (2013).
pubmed: 23352221
pmcid: 3610532
Jones, R. G. & Pearce, E. J. MenTORing immunity: mTOR signaling in the development and function of tissue-resident immune cells. Immunity 46, 730–742 (2017).
pubmed: 28514674
pmcid: 5695239
Pollizzi, K. N. & Powell, J. D. Regulation of T cells by mTOR: the known knowns and the known unknowns. Trends Immunol. 36, 13–20 (2015).
pubmed: 25522665
Macintyre, A. N., Finlay, D., Preston, G., Sinclair, L. V., Waugh, C. M. & Tamas, P. et al. Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism. Immunity 34, 224–236 (2011).
pubmed: 21295499
pmcid: 3052433
Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L. & Rolf, J. et al. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J. Exp. Med. 209, 2441–2453 (2012).
pubmed: 23183047
pmcid: 3526360
Hamilton, K. S., Phong, B., Corey, C., Cheng, J., Gorentla, B. & Zhong, X. et al. T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10. Sci. Signal 7, ra55 (2014).
pubmed: 24917592
pmcid: 4405131
Deiss, L. P., Feinstein, E., Berissi, H., Cohen, O. & Kimchi, A. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 9, 15–30 (1995).
pubmed: 7828849
Singh, P., Ravanan, P. & Talwar, P. Death associated protein kinase 1 (DAPK1): a regulator of apoptosis and autophagy. Front. Mol. Neurosci. 9, 46 (2016).
pubmed: 27445685
pmcid: 4917528
Shohat, G., Spivak-Kroizman, T., Cohen, O., Bialik, S., Shani, G. & Berrisi, H. et al. The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism. J. Biol. Chem. 276, 47460–47467 (2001).
pubmed: 11579085
Shohat, G., Shani, G., Eisenstein, M. & Kimchi, A. The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases. Biochim. Biophys. Acta 1600, 45–50 (2002).
pubmed: 12445458
Stevens, C., Lin, Y., Harrison, B., Burch, L., Ridgway, R. A. & Sansom, O. et al. Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling. J. Biol. Chem. 284, 334–344 (2009).
pubmed: 18974095
Shiloh, R., Bialik, S. & Kimchi, A. The DAPK family: a structure-function analysis. Apoptosis 19, 286–297 (2014).
pubmed: 24220854
Zhao, J., Zhao, D., Poage, G. M., Mazumdar, A., Zhang, Y. & Hill, J. L. et al. Death-associated protein kinase 1 promotes growth of p53-mutant cancers. J. Clin. Investig. 125, 2707–2720 (2015).
pubmed: 26075823
Chuang, Y. T., Fang, L. W., Lin-Feng, M. H., Chen, R. H. & Lai, M. Z. The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappa B activation. J. Immunol. 180, 3238–3249 (2008).
pubmed: 18292548
Chou, T. F., Chuang, Y. T., Hsieh, W. C., Chang, P. Y., Liu, H. Y. & Mo, S. T. et al. Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1alpha for Th17 suppression. Nat. Commun. 7, 11904 (2016).
pubmed: 27312851
pmcid: 4915028
McGargill, M. A., Wen, B. G., Walsh, C. M. & Hedrick, S. M. A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity. Immunity 21, 781–791 (2004).
pubmed: 15589167
pmcid: 2792702
Pei, L., Wang, S., Jin, H., Bi, L., Wei, N. & Yan, H. et al. A novel mechanism of spine damages in stroke via DAPK1 and Tau. Cereb. Cortex 25, 4559–4571 (2015).
pubmed: 25995053
pmcid: 4816799
Shu, S., Zhu, H., Tang, N., Chen, W., Li, X. & Li, H. et al. Selective degeneration of entorhinal-CA1 synapses in Alzheimer’s disease via activation of DAPK1. J. Neurosci. 36, 10843–10852 (2016).
pubmed: 27798139
pmcid: 5083012
Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Murillo, A. B. & Hawkins, P. T. et al. The cytotoxic T cell proteome and its shaping by the kinase mTOR. Nat. Immunol. 17, 104–112 (2016).
pubmed: 26551880
Ross, S. H., Rollings, C., Anderson, K. E., Hawkins, P. T., Stephens, L. R. & Cantrell, D. A. Phosphoproteomic analyses of interleukin 2 signaling reveal integrated JAK kinase-dependent and -independent networks in CD8(+) T cells. Immunity 45, 685–700 (2016).
pubmed: 27566939
pmcid: 5040828
Potter, C. J., Pedraza, L. G. & Xu, T. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4, 658–665 (2002).
pubmed: 12172554
Salmond, R. J., Emery, J., Okkenhaug, K. & Zamoyska, R. MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J. Immunol. 183, 7388–7397 (2009).
pubmed: 19917692
Salmond, R. J., Brownlie, R. J., Meyuhas, O. & Zamoyska, R. Mechanistic target of rapamycin complex 1/S6 kinase 1 signals influence T cell activation independently of ribosomal protein S6 phosphorylation. J. Immunol. 195, 4615–4622 (2015).
pubmed: 26453749
pmcid: 4635570
Liu, W. L., Yang, H. C., Hsu, C. S., Wang, C. C., Wang, T. S. & Kao, J. H. et al. Pegylated IFN-alpha suppresses hepatitis C virus by promoting the DAPK-mTOR pathway. Proc. Natl Acad. Sci. USA 113, 14799–14804 (2016).
pubmed: 27930338
Zeng, H. & Chi, H. mTOR signaling in the differentiation and function of regulatory and effector T cells. Curr. Opin. Immunol. 46, 103–111 (2017).
pubmed: 28535458
pmcid: 5554750