Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics.
Journal
Current opinion in chemical biology
ISSN: 1879-0402
Titre abrégé: Curr Opin Chem Biol
Pays: England
ID NLM: 9811312
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
14
02
2019
revised:
07
05
2019
accepted:
06
06
2019
pubmed:
22
9
2019
medline:
3
4
2020
entrez:
22
9
2019
Statut:
ppublish
Résumé
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide mimetics. Salient features include the stability of hybridization complexes (either as duplexes or triplexes), metabolic stability, and ease of chemical modifications. These features have enabled important applications such as antisense agents, gene editing, nucleic acid sensing and as a platform to program the assembly of PNA-tagged molecules. Here, we review recent advances in these areas.
Identifiants
pubmed: 31541865
pii: S1367-5931(19)30008-0
doi: 10.1016/j.cbpa.2019.06.006
pii:
doi:
Substances chimiques
Antisense Elements (Genetics)
0
Molecular Probes
0
Nucleic Acids
0
Peptide Nucleic Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
112-124Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.