Alcohol use disorder and cannabis use disorder symptomatology in adolescents are differentially related to dysfunction in brain regions supporting face processing.
Adolescence
Alcohol
Cannabis
Expressions
Faces
fMRI
Journal
Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001
Informations de publication
Date de publication:
30 10 2019
30 10 2019
Historique:
received:
09
02
2019
revised:
09
09
2019
accepted:
12
09
2019
pubmed:
22
9
2019
medline:
9
4
2020
entrez:
22
9
2019
Statut:
ppublish
Résumé
Despite extensive behavioral evidence of impairments in face processing and expression recognition in adults with alcohol or cannabis use disorders (AUD/CUD), neuroimaging findings have been inconsistent. Moreover, relatively little work has examined the relationship of AUD or CUD symptoms with face or expression processing within adolescents. Given the high prevalence of alcohol and cannabis use during adolescence, understanding how these usage behaviors interact with neural mechanisms supporting face and expression processing could have important implications for youth social and emotional functioning. In this study, adolescents (N = 104) responded to morphed fearful and happy expressions during fMRI and their level of AUD and/or CUD symptoms were related to the BOLD response data. We found that AUD and CUD symptom severity were both negatively related to responses to faces generally. However, whereas this relationship was shown for AUD within ventromedial prefrontal cortex and lingual gyrus, it was shown for CUD within rostromedial prefrontal cortex including anterior cingulate cortex. Additionally, AUD symptom levels were associated with differential responses within medial temporal pole and inferior parietal lobule as a function of expression. These results have potential implications for understanding the social and emotional functioning of adolescents with AUD and CUD symptoms.
Identifiants
pubmed: 31541926
pii: S0925-4927(19)30045-9
doi: 10.1016/j.pscychresns.2019.09.004
pmc: PMC6992382
mid: NIHMS1065005
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
62-71Subventions
Organisme : NIMH NIH HHS
ID : K01 MH110643
Pays : United States
Organisme : NIMH NIH HHS
ID : K22 MH109558
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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