Gangliosides Destabilize Lipid Phase Separation in Multicomponent Membranes.
Journal
Biophysical journal
ISSN: 1542-0086
Titre abrégé: Biophys J
Pays: United States
ID NLM: 0370626
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
received:
19
04
2019
revised:
15
07
2019
accepted:
30
08
2019
pubmed:
23
9
2019
medline:
22
9
2020
entrez:
23
9
2019
Statut:
ppublish
Résumé
Gangliosides (GMs) form an important class of lipids found in the outer leaflet of the plasma membrane. Typically, they colocalize with cholesterol and sphingomyelin in ordered membrane domains. However, detailed understanding of the lateral organization of GM-rich membranes is still lacking. To gain molecular insight, we performed molecular dynamics simulations of GMs in model membranes composed of coexisting liquid-ordered and liquid-disordered domains. We found that GMs indeed have a preference to partition into the ordered domains. At higher concentrations (>10 mol %), we observed a destabilizing effect of GMs on the phase coexistence. Further simulations with modified GMs show that the structure of the GM headgroup affects the phase separation, whereas the nature of the tail determines the preferential location. Together, our findings provide a molecular basis to understand the lateral organization of GM-rich membranes.
Identifiants
pubmed: 31542224
pii: S0006-3495(19)30754-4
doi: 10.1016/j.bpj.2019.08.037
pmc: PMC6818149
pii:
doi:
Substances chimiques
Gangliosides
0
Lipid Bilayers
0
Oligosaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1215-1223Informations de copyright
Copyright © 2019 Biophysical Society. Published by Elsevier Inc. All rights reserved.
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