Diffusion-Weighted MR Imaging to Evaluate Immediate Response to Irreversible Electroporation in a Rabbit VX2 Liver Tumor Model.

Ablation Techniques Animals Apoptosis Cell Line, Tumor Diffusion Magnetic Resonance Imaging Electroporation Feasibility Studies Liver Neoplasms / diagnostic imaging Predictive Value of Tests Rabbits

Journal

Journal of vascular and interventional radiology : JVIR
ISSN: 1535-7732
Titre abrégé: J Vasc Interv Radiol
Pays: United States
ID NLM: 9203369

Informations de publication

Date de publication:
Nov 2019
Historique:
received: 23 01 2019
revised: 26 05 2019
accepted: 31 05 2019
pubmed: 23 9 2019
medline: 3 3 2020
entrez: 23 9 2019
Statut: ppublish

Résumé

To evaluate the feasibility of diffusion-weighted imaging (DWI) in magnetic resonance imaging for quantitative measurement of responses following irreversible electroporation (IRE) in a rabbit liver tumor model. Twelve rabbits underwent ultrasound-guided VX2 tumor implantation in the left medial and left lateral liver lobes. The tumors in the left medial lobe were treated with IRE, whereas those in the left lateral lobe served as internal controls. DWI was performed before and immediately after IRE. Tumors were then harvested for histopathologic staining. The apparent diffusion coefficient (ADC) and change in ADC (ΔADC) were calculated based on DWI. Tumor apoptosis index (AI) was assessed by terminal deoxynucleotidyl transferase dUTP nick-end labeling. These measurements from DWI and histopathology were compared between untreated and treated tumors. The ADC values, ΔADC, and AI showed statistically significant differences between treated and untreated tumors (P < .05 for all). ADC values were higher in treated tumors than in untreated tumors (1.08 × 10 DWI can be used to quantitatively evaluate treatment response in liver tumors immediately after IRE.

Identifiants

DOI: 10.1016/j.jvir.2019.05.030 PMID: 31542271
pubmed: 31542271
pii: S1051-0443(19)30540-8
doi: 10.1016/j.jvir.2019.05.030
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1863-1869

Informations de copyright

Published by Elsevier Inc.

Auteurs

Su Hu (S)

Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China; Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., 16th Floor, Chicago, IL 60611.

Chong Sun (C)

Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao, China.

Bin Wang (B)

Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., 16th Floor, Chicago, IL 60611; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangdong Provincial Engineering Technology Research Center of Minimally Invasive Surgery, Guangzhou, China.

Kang Zhou (K)

Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., 16th Floor, Chicago, IL 60611; Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Liang Pan (L)

Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., 16th Floor, Chicago, IL 60611; Department of Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Junjie Shangguan (J)

Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., 16th Floor, Chicago, IL 60611.

Jia Yang (J)

Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., 16th Floor, Chicago, IL 60611.

Vahid Yaghmai (V)

Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., 16th Floor, Chicago, IL 60611; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois.

Matteo Figini (M)

Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., 16th Floor, Chicago, IL 60611.

Zhuoli Zhang (Z)

Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., 16th Floor, Chicago, IL 60611; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois. Electronic address: zhuoli-zhang@northwestern.edu.

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Classifications MeSH

questionsmedicales.fr › Procédures de chirurgie opératoire › Techniques d'ablation › Diffusion-Weighted MR Imaging to Evaluate...
questionsmedicales.fr › Eucaryotes › Animaux › Diffusion-Weighted MR Imaging to Evaluate...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Diffusion-Weighted MR Imaging to Evaluate...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Diffusion-Weighted MR Imaging to Evaluate...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Imagerie par résonance magnétique de diffusion › Diffusion-Weighted MR Imaging to Evaluate...
questionsmedicales.fr › Techniques d'investigation › Techniques électrochimiques › Électroporation › Diffusion-Weighted MR Imaging to Evaluate...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études de faisabilité › Diffusion-Weighted MR Imaging to Evaluate...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Diffusion-Weighted MR Imaging to Evaluate...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Valeur prédictive des tests › Diffusion-Weighted MR Imaging to Evaluate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › Diffusion-Weighted MR Imaging to Evaluate...