The 5-hydroxytryptamine receptor 1F stimulates mitochondrial biogenesis and angiogenesis in endothelial cells.
Acute Kidney Injury
/ etiology
Animals
Benzamides
/ pharmacology
Carbazoles
/ pharmacology
Cells, Cultured
Endothelial Cells
/ physiology
Fluorobenzenes
/ pharmacology
Kidney
/ blood supply
Male
Mice
Mice, Inbred C57BL
Neovascularization, Physiologic
/ physiology
Organelle Biogenesis
Piperidines
/ pharmacology
Pyridines
/ pharmacology
Receptors, Serotonin
/ physiology
Receptor, Serotonin, 5-HT1F
Angiogenesis
Endothelial cells
Mitochondrial biogenesis
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
29
07
2019
accepted:
17
09
2019
pubmed:
23
9
2019
medline:
14
7
2020
entrez:
23
9
2019
Statut:
ppublish
Résumé
A hallmark of acute kidney injury (AKI) is vascular rarefication and mitochondrial dysfunction. Promoting vascular recovery following AKI could facilitate kidney repair as the vasculature is responsible for oxygen and nutrient delivery to extravascular tissues. Little is known about mitochondrial biogenesis (MB) in endothelial cells, and the role of 5-HT
Identifiants
pubmed: 31542386
pii: S0006-2952(19)30343-0
doi: 10.1016/j.bcp.2019.113644
pmc: PMC7749638
mid: NIHMS1543779
pii:
doi:
Substances chimiques
Benzamides
0
Carbazoles
0
Fluorobenzenes
0
LY 344864
0
Piperidines
0
Pyridines
0
Receptors, Serotonin
0
lasmiditan
760I9WM792
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
113644Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM084147
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007249
Pays : United States
Organisme : BLRD VA
ID : I01 BX000851
Pays : United States
Organisme : NIH HHS
ID : F32 DK120222-01A1
Pays : United States
Organisme : NIDDK NIH HHS
ID : F32 DK120222
Pays : United States
Organisme : NIH HHS
ID : S10 OD011981
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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