Examining the effects of creatine supplementation in augmenting adaptations to resistance training in patients with prostate cancer undergoing androgen deprivation therapy: a randomised, double-blind, placebo-controlled trial.
body composition
fat free mass
hormone therapy
muscle mass
strength
weight training
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
20 09 2019
20 09 2019
Historique:
entrez:
23
9
2019
pubmed:
23
9
2019
medline:
2
10
2020
Statut:
epublish
Résumé
Creatine supplementation has consistently been demonstrated to augment adaptations in body composition, muscle strength and physical function in a variety of apparently healthy older adults and clinical populations. The effects of creatine supplementation and resistance training in individuals with cancer have yet to be investigated. This study aims to examine the effects of creatine supplementation in conjunction with resistance training on body composition, muscle strength and physical function in prostate cancer patients undergoing androgen deprivation therapy. This is a randomised, double-blind, placebo-controlled trial designed to examine the effects of creatine supplementation in addition to resistance training in patients with prostate cancer receiving androgen deprivation therapy. Both supplement and placebo groups will receive a 12-week supervised exercise programme comprising resistance training undertaken three times per week. The primary endpoint (fat-free mass) and secondary endpoints (fat mass, per cent body fat, physical fitness, quality of life and blood biomarkers) will be assessed at baseline and immediately following the intervention. The Human Research Ethics Committee of Edith Cowan University approved this study (ID: 22243 FAIRMAN). If the results of this trial demonstrate that creatine supplementation can augment beneficial adaptations of body composition, physical function and/or psychosocial outcomes to resistance training, this study will provide effect sizes that will inform the design of subsequent definitive randomised controlled trials. The results of this study will be published in peer-reviewed journals and presented at various national and international conferences. ACTRN12619000099123.
Identifiants
pubmed: 31542747
pii: bmjopen-2019-030080
doi: 10.1136/bmjopen-2019-030080
pmc: PMC6756416
doi:
Substances chimiques
Androgen Antagonists
0
Creatine
MU72812GK0
Banques de données
ANZCTR
['ACTRN12619000099123']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
e030080Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
J Psychosom Res. 2013 Jan;74(1):64-8
pubmed: 23272990
J Nutr Health Aging. 2010 Feb;14(2):155-9
pubmed: 20126965
Clin Sci (Lond). 1992 Sep;83(3):367-74
pubmed: 1327657
Arch Phys Med Rehabil. 2015 Jan;96(1):7-14
pubmed: 25194450
J Gerontol A Biol Sci Med Sci. 2003 Jan;58(1):11-9
pubmed: 12560406
BMC Cancer. 2018 Apr 3;18(1):368
pubmed: 29614993
Neurology. 2004 May 25;62(10):1771-7
pubmed: 15159476
J Cachexia Sarcopenia Muscle. 2014 Jun;5(2):105-10
pubmed: 24676930
J Cancer Surviv. 2017 Jun;11(3):339-349
pubmed: 28054255
Med Sci Sports Exerc. 2018 Mar;50(3):393-399
pubmed: 29036016
J Int Soc Sports Nutr. 2007 Aug 30;4:6
pubmed: 17908288
Eur J Cancer. 2019 Jan;107:153-163
pubmed: 30576971
Amino Acids. 2007;32(4):467-77
pubmed: 16988909
Exp Gerontol. 2015 Oct;70:97-104
pubmed: 26192975
Eur J Appl Physiol. 2011 May;111(5):749-56
pubmed: 20976468
Med Sci Sports Exerc. 2002 Mar;34(3):537-43
pubmed: 11880821
BJU Int. 2015 Apr;115 Suppl 5:3-13
pubmed: 25327530
Eur J Appl Physiol. 2008 Jan;102(2):223-31
pubmed: 17943308
Nutr Res Rev. 2017 Dec;30(2):220-232
pubmed: 28606220
J Gerontol A Biol Sci Med Sci. 2004 Mar;59(3):255-63
pubmed: 15031310
Respirology. 2010 Jul;15(5):785-95
pubmed: 20497386
J Physiol. 2006 Jun 1;573(Pt 2):525-34
pubmed: 16581862
Eur Urol. 2014 May;65(5):856-64
pubmed: 24113319
Eur J Cancer. 2008 Nov;44(16):2418-24
pubmed: 18774706
Prostate Cancer Prostatic Dis. 2007;10(4):340-6
pubmed: 17486110
Cancer. 2015 Jul 15;121(14):2465-73
pubmed: 25845467
Urology. 2008 Apr;71(4):735-9
pubmed: 18279933
J Nutr Health Aging. 2007 Nov-Dec;11(6):459-64
pubmed: 17985060
Support Care Cancer. 2016 May;24(5):2201-2207
pubmed: 26563183
PLoS One. 2009;4(2):e4605
pubmed: 19242554
Open Access J Sports Med. 2017 Nov 02;8:213-226
pubmed: 29138605
BJU Int. 2018 Dec;122(6):986-993
pubmed: 29750398
J Cachexia Sarcopenia Muscle. 2016 Sep;7(4):413-21
pubmed: 27239423
Exp Gerontol. 2014 May;53:7-15
pubmed: 24530883
Med Sci Sports Exerc. 2014 Jun;46(6):1194-203
pubmed: 24576864
Curr Sports Med Rep. 2002 Jun;1(3):165-71
pubmed: 12831709
Med Sci Sports Exerc. 2009 Mar;41(3):687-708
pubmed: 19204579
Trials. 2017 Oct 3;18(1):451
pubmed: 28974267
Amino Acids. 2010 Jan;38(1):31-44
pubmed: 19253023
Neurology. 2006 Oct 10;67(7):1262-4
pubmed: 17030762
Sports Med. 2015 Sep;45(9):1285-1294
pubmed: 25946994
Clin Rehabil. 2010 Nov;24(11):988-99
pubmed: 20576665
Aging Male. 2005 Sep-Dec;8(3-4):207-12
pubmed: 16390748
Med Sci Sports Exerc. 2019 Apr;51(4):607-614
pubmed: 30395051
J Int Soc Sports Nutr. 2017 Jun 13;14:18
pubmed: 28615996
Med Sci Sports Exerc. 2008 Sep;40(9):1645-52
pubmed: 18685526
Front Endocrinol (Lausanne). 2012 Feb 16;3:17
pubmed: 22645517
Crit Rev Oncol Hematol. 2019 Jan;133:46-57
pubmed: 30661658
Med Sci Sports Exerc. 2018 Jun;50(6):1134-1141
pubmed: 29315168
Eur Heart J. 1998 Apr;19(4):617-22
pubmed: 9597411
BJU Int. 2008 Jul;102(1):44-7
pubmed: 18336606
J Clin Oncol. 2010 Jan 10;28(2):340-7
pubmed: 19949016
J Sports Sci Med. 2015 Aug 11;14(3):620-6
pubmed: 26336349
Ann Behav Med. 2018 Apr 19;52(5):412-428
pubmed: 29684136
Eur J Appl Physiol. 2013 Apr;113(4):987-96
pubmed: 23053133
BMJ Open. 2017 Jul 10;7(7):e016910
pubmed: 28698349
J Strength Cond Res. 2006 Feb;20(1):22-8
pubmed: 16503684
Eur J Cancer. 2016 Apr;57:58-67
pubmed: 26882087
Clin Cancer Res. 2017 Jul 15;23(14):3537-3543
pubmed: 28143874