[Physiopathology of giant cell arteritis: From inflammation to vascular remodeling].
Physiopathologie de l’artérite à cellules géantes : de l’inflammation au remodelage vasculaire.
Animals
B-Lymphocytes
/ physiology
CD4-Positive T-Lymphocytes
/ physiology
Cell Movement
Cell Proliferation
Dendritic Cells
/ physiology
Disease Models, Animal
Genetic Predisposition to Disease
Giant Cell Arteritis
/ drug therapy
Humans
Interferon-gamma
/ metabolism
Interleukin-17
/ metabolism
Interleukin-33
/ metabolism
Interleukin-6
/ physiology
Interleukins
/ biosynthesis
Lymphocyte Activation
/ physiology
Macrophages
/ metabolism
Matrix Metalloproteinases
/ metabolism
Muscle, Smooth, Vascular
/ pathology
Neovascularization, Pathologic
/ physiopathology
T-Lymphocytes, Regulatory
/ physiology
Th17 Cells
/ physiology
Vascular Remodeling
/ physiology
Journal
Presse medicale (Paris, France : 1983)
ISSN: 2213-0276
Titre abrégé: Presse Med
Pays: France
ID NLM: 8302490
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
07
04
2019
revised:
10
07
2019
accepted:
23
07
2019
pubmed:
24
9
2019
medline:
18
10
2019
entrez:
24
9
2019
Statut:
ppublish
Résumé
Giant cell arteritis (GCA) is a large-vessel vasculitis involving the aorta and its main branches, especially supra aortic branches. Although much progress has been made, the pathophysiology remains incompletely understood. An initial trigger, suspected of infectious origin, lead to the maturation and recruitment of dendritic cells (DC). The lack of migration of these DC allows the local recruitment of T-lymphocytes (LT). These LT- CD4
Identifiants
pubmed: 31543394
pii: S0755-4982(19)30343-4
doi: 10.1016/j.lpm.2019.07.031
pii:
doi:
Substances chimiques
IL33 protein, human
0
Interleukin-17
0
Interleukin-33
0
Interleukin-6
0
Interleukins
0
Interferon-gamma
82115-62-6
Matrix Metalloproteinases
EC 3.4.24.-
interleukin-21
MKM3CA6LT1
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
919-930Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.