The Māori and Pacific specific CREBRF variant and adult height.
Journal
International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
21
03
2019
accepted:
07
07
2019
revised:
24
06
2019
pubmed:
24
9
2019
medline:
11
5
2021
entrez:
24
9
2019
Statut:
ppublish
Résumé
The CREBRF missense variant (p.Arg457Gln) is paradoxically associated with lower risk of type 2 diabetes, yet higher body mass index (BMI). Here we sought to determine whether this CREBRF variant might be associated with adult height. Linear regression was used to analyse the association of the CREBRF minor (A) allele with height in 2286 Māori and Pacific adults living in Aotearoa/New Zealand. A potential type 2 diabetes index event was corrected to account for a bias that may be the cause of paradoxical association between the CREBRF diabetes-protective allele and higher BMI and height. The CREBRF protective allele was associated with increased adult height (ß = 1.25 cm, P = 3.9 × 10 These data taken together indicate that CREBRF p.Arg457Gln is associated with taller stature in Māori and Pacific adults.
Sections du résumé
BACKGROUND
The CREBRF missense variant (p.Arg457Gln) is paradoxically associated with lower risk of type 2 diabetes, yet higher body mass index (BMI). Here we sought to determine whether this CREBRF variant might be associated with adult height.
METHODS
Linear regression was used to analyse the association of the CREBRF minor (A) allele with height in 2286 Māori and Pacific adults living in Aotearoa/New Zealand. A potential type 2 diabetes index event was corrected to account for a bias that may be the cause of paradoxical association between the CREBRF diabetes-protective allele and higher BMI and height.
RESULTS
The CREBRF protective allele was associated with increased adult height (ß = 1.25 cm, P = 3.9 × 10
CONCLUSION
These data taken together indicate that CREBRF p.Arg457Gln is associated with taller stature in Māori and Pacific adults.
Identifiants
pubmed: 31543511
doi: 10.1038/s41366-019-0437-6
pii: 10.1038/s41366-019-0437-6
doi:
Substances chimiques
CREB3 regulatory factor, human
0
Tumor Suppressor Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
748-752Références
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