Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling.
Bacteria
/ metabolism
Fatty Acids, Volatile
/ pharmacology
Gastrointestinal Microbiome
Gene Expression Regulation
/ drug effects
Ghrelin
/ pharmacology
HEK293 Cells
Humans
Lactic Acid
/ pharmacology
Mitogen-Activated Protein Kinase 1
/ genetics
Mitogen-Activated Protein Kinase 3
/ genetics
Receptors, Ghrelin
/ genetics
Signal Transduction
TOR Serine-Threonine Kinases
/ genetics
GHSR-1a
SCFA
gut bacteria
lactate
probiotics
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
pubmed:
24
9
2019
medline:
10
6
2020
entrez:
24
9
2019
Statut:
ppublish
Résumé
The gastrointestinal microbiota is emerging as a unique and inexhaustible source for metabolites with potential to modulate G-protein coupled receptors (GPCRs). The ghrelin receptor [growth hormone secretagogue receptor (GHSR)-1a] is a GPCR expressed throughout both the gut and the brain and plays a crucial role in maintaining energy balance, metabolism, and the central modulation of food intake, motivation, reward, and mood. To date, few studies have investigated the potential of the gastrointestinal microbiota and its metabolites to modulate GPCR signaling. Here we investigate the ability of short-chain fatty acids (SCFAs), lactate, and different bacterial strains, including
Identifiants
pubmed: 31545915
doi: 10.1096/fj.201901433R
doi:
Substances chimiques
Fatty Acids, Volatile
0
Ghrelin
0
Ghsr1a protein, human
0
Receptors, Ghrelin
0
Lactic Acid
33X04XA5AT
MTOR protein, human
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
MAPK1 protein, human
EC 2.7.11.24
MAPK3 protein, human
EC 2.7.11.24
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13546-13559Références
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