New triazinoindole bearing thiazole/oxazole analogues: Synthesis, α-amylase inhibitory potential and molecular docking study.

Dose-Response Relationship, Drug Glycoside Hydrolase Inhibitors / chemical synthesis Humans Molecular Docking Simulation Molecular Structure Oxazoles / chemistry Structure-Activity Relationship Thiazoles / chemistry Triazines / chemical synthesis alpha-Amylases / antagonists & inhibitors
Molecular docking Oxazole SAR Synthesis Thiazole Triazinoindole α-amylase

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
11 2019
Historique:
received: 10 04 2019
revised: 12 09 2019
accepted: 14 09 2019
pubmed: 24 9 2019
medline: 21 10 2020
entrez: 24 9 2019
Statut: ppublish

Résumé

New triazinoindole bearing thiazole/oxazole analogues (1-21) were synthesized and characterized through spectroscopic techniques such as HREI-MS,

Identifiants

DOI: 10.1016/j.bioorg.2019.103284 PMID: 31546207
pubmed: 31546207
pii: S0045-2068(19)30554-1
doi: 10.1016/j.bioorg.2019.103284
pii:
doi:

Substances chimiques

Glycoside Hydrolase Inhibitors 0
Oxazoles 0
Thiazoles 0
Triazines 0
alpha-Amylases EC 3.2.1.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103284

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Fazal Rahim (F)

Department of Chemistry, Hazara University, Mansehra 21300, Khyber Pakhtunkhwa, Pakistan. Electronic address: fazalstar@gmail.com.

Sundas Tariq (S)

Department of Chemistry, Hazara University, Mansehra 21300, Khyber Pakhtunkhwa, Pakistan.

Muhammad Taha (M)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia. Electronic address: mtaha@iau.edu.sa.

Hayat Ullah (H)

Department of Chemistry, Hazara University, Mansehra 21300, Khyber Pakhtunkhwa, Pakistan.

Khalid Zaman (K)

Department of Chemistry, Hazara University, Mansehra 21300, Khyber Pakhtunkhwa, Pakistan.

Imad Uddin (I)

Department of Chemistry, Hazara University, Mansehra 21300, Khyber Pakhtunkhwa, Pakistan.

Abdul Wadood (A)

Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.

Aftab Ahmad Khan (AA)

Department of Chemistry, Hazara University, Mansehra 21300, Khyber Pakhtunkhwa, Pakistan.

Ashfaq Ur Rehman (AU)

Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.

Nizam Uddin (N)

Department of Chemistry, University of Karachi, Karachi 75270, Pakistan.

Salman Zafar (S)

Institute of Chemical Science, University of Peshawar, Khyber Pakhtunkhwa, Pakistan.

Syed Adnan Ali Shah (SAA)

Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor D.E., Malaysia; Faculty of Pharmacy, Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor D.E., Malaysia.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › New triazinoindole bearing thiazole/oxazole...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › New triazinoindole bearing thiazole/oxazole...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › New triazinoindole bearing thiazole/oxazole...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › New triazinoindole bearing thiazole/oxazole...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › New triazinoindole bearing thiazole/oxazole...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › New triazinoindole bearing thiazole/oxazole...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › New triazinoindole bearing thiazole/oxazole...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Thiazoles › New triazinoindole bearing thiazole/oxazole...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Triazines › New triazinoindole bearing thiazole/oxazole...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Amylases › alpha-Amylases › New triazinoindole bearing thiazole/oxazole...