In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8


Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
01 11 2019
Historique:
received: 23 01 2019
accepted: 24 08 2019
pubmed: 25 9 2019
medline: 29 5 2020
entrez: 25 9 2019
Statut: ppublish

Résumé

Flotillin-1 (Flot1) is an evolutionary conserved, ubiquitously expressed lipid raft-associated scaffolding protein. Migration of Flot1-deficient neutrophils is impaired because of a decrease in myosin II-mediated contractility. Flot1 also accumulates in the uropod of polarized T cells, suggesting an analogous role in T cell migration. In this study, we analyzed morphology and migration parameters of murine wild-type and Flot1

Identifiants

pubmed: 31548330
pii: jimmunol.1900075
doi: 10.4049/jimmunol.1900075
pmc: PMC6820809
mid: EMS84620
doi:

Substances chimiques

Membrane Proteins 0
flotillins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2377-2387

Subventions

Organisme : Swiss National Science Foundation
ID : 172994
Pays : Switzerland

Informations de copyright

Copyright © 2019 by The American Association of Immunologists, Inc.

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Auteurs

Xenia Ficht (X)

Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.

Nora Ruef (N)

Department of Oncology, Microbiology and Immunology, University of Fribourg, 1700 Fribourg, Switzerland.

Bettina Stolp (B)

Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.
Department for Infectious Diseases, Integrative Virology, Center for Integrative Infectious Disease Research, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Guerric P B Samson (GPB)

Biotechnology Institute Thurgau at the University of Konstanz, 8280 Kreuzlingen, Switzerland.

Federica Moalli (F)

Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.
Scientific Institute for Research and Healthcare, San Raffaele Scientific Institute, 20132 Milan, Italy.

Nicolas Page (N)

Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.

Doron Merkler (D)

Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.

Ben J Nichols (BJ)

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

Alba Diz-Muñoz (A)

Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany; and.

Daniel F Legler (DF)

Biotechnology Institute Thurgau at the University of Konstanz, 8280 Kreuzlingen, Switzerland.

Verena Niggli (V)

Institute of Pathology, University of Bern, 3008 Bern, Switzerland.

Jens V Stein (JV)

Department of Oncology, Microbiology and Immunology, University of Fribourg, 1700 Fribourg, Switzerland; jens.stein@unifr.ch.

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Classifications MeSH