Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases.
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
14
02
2019
accepted:
30
07
2019
pubmed:
25
9
2019
medline:
23
1
2020
entrez:
25
9
2019
Statut:
ppublish
Résumé
Immune-disease-associated variants are enriched in active chromatin regions of T cells and macrophages. However, whether these variants function in specific cell states is unknown. Here we stimulated T cells and macrophages in the presence of 13 cytokines and profiled active and open chromatin regions. T cell activation induced major chromatin remodeling, while the presence of cytokines fine-tuned the magnitude of changes. We developed a statistical method that accounts for subtle changes in the chromatin landscape to identify SNP enrichment across cell states. Our results point towards the role of immune-disease-associated variants in early rather than late activation of memory CD4
Identifiants
pubmed: 31548716
doi: 10.1038/s41588-019-0493-9
pii: 10.1038/s41588-019-0493-9
pmc: PMC6872452
mid: EMS83888
doi:
Substances chimiques
Chromatin
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1486-1493Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206194
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N014995/1
Pays : United Kingdom
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