Crizotinib inhibition of
Carcinoma, Non-Small-Cell Lung
/ drug therapy
Crizotinib
/ therapeutic use
Female
Humans
Lung Neoplasms
/ drug therapy
Oncogene Proteins, Fusion
/ genetics
Practice Guidelines as Topic
Protein Kinase Inhibitors
/ therapeutic use
Protein-Tyrosine Kinases
/ genetics
Proto-Oncogene Proteins
/ genetics
Retrospective Studies
Survival Analysis
Treatment Outcome
ROS1
crizotinib
molecular testing
non-small-cell lung cancer, advanced
nsclc, advanced
nsclc, nonsquamous
oncogenic drivers
targeted therapy
Journal
Current oncology (Toronto, Ont.)
ISSN: 1718-7729
Titre abrégé: Curr Oncol
Pays: Switzerland
ID NLM: 9502503
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
entrez:
25
9
2019
pubmed:
25
9
2019
medline:
15
5
2020
Statut:
ppublish
Résumé
The ros1 kinase is an oncogenic driver in non-small-cell lung cancer (nsclc). Fusion events involving the
Identifiants
pubmed: 31548824
doi: 10.3747/co.26.5137
pii: conc-26-e551
pmc: PMC6726257
doi:
Substances chimiques
Oncogene Proteins, Fusion
0
Protein Kinase Inhibitors
0
Proto-Oncogene Proteins
0
Crizotinib
53AH36668S
Protein-Tyrosine Kinases
EC 2.7.10.1
ROS1 protein, human
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e551-e557Déclaration de conflit d'intérêts
CONFLICT OF INTEREST DISCLOSURES We have read and understood Current Oncology’s policy on disclosing conflicts of interest, and we declare the following interests: JA, SB, ACS have received personal fees from Pfizer, outside the submitted work; RA received personal fees from Pfizer during the conduct of the study; DGB received grants from Pfizer during the conduct of the study and personal fees from AstraZeneca, Roche, Bristol–Myers Squibb, Boehringer Ingelheim, Pfizer, Merck, Bayer, Lilly, and Takeda outside the submitted work; GB and WM are members of the Pfizer advisory board; CB and CC have received other consideration from Pfizer outside the submitted work; PD received grants from Pfizer during the conduct of the study and other consideration from Bayer, Bristol–Myers Squibb, AstraZeneca, and Pfizer outside the submitted work; HSS has received other consideration from Pfizer Canada, Bayer, Merck, and EMD Serono Canada outside the submitted work; TLS has received grants and personal fees from AstraZeneca and personal fees from Bristol–Myers Squibb, Janssen, Pfizer, and Novartis outside the submitted work; ET has received grants from, and been an advisory board member for, Pfizer, Bristol–Myers Squibb, Merck, AstraZeneca, Roche, and Janssen outside the submitted work; MST received grants and personal fees from Pfizer during the conduct of the study and has received grants and personal fees from AstraZeneca and Merck, and personal fees from Bristol–Myers Squibb and Bayer outside the submitted work; JCC, DNI, NBL, BM, FRK, and ZX have no conflicts to disclose.
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