Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis.
Female
Ferritins
/ blood
Fever
/ metabolism
Herpes Simplex
/ blood
Humans
Infant, Newborn
Interferon-beta
/ blood
Interferon-gamma
/ blood
Interleukin-6
/ blood
Kaplan-Meier Estimate
Lymphohistiocytosis, Hemophagocytic
/ blood
Male
Platelet Count
Pregnancy Complications, Infectious
Prognosis
Receptors, Interleukin-2
/ blood
Toll-Like Receptor 3
/ blood
Tumor Necrosis Factor-alpha
/ blood
Hemophagocytic lymphohistiocytosis
Herpes simplex virus
Neonate
Prognostic factor
Toll-like receptor 3
Journal
International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
07
06
2019
accepted:
17
09
2019
revised:
17
09
2019
pubmed:
25
9
2019
medline:
17
6
2020
entrez:
25
9
2019
Statut:
ppublish
Résumé
Hemophagocytic lymphohistiocytosis (HLH) occurs in neonates with disseminated infection of herpes simplex virus (HSV). Little has been reported on the control of rapid HLH progression. We studied the cytokine profile and genetic basis of two index cases with divergent outcomes after early treatment of type 2 HSV infection. One survivor had fever and elevated serum levels of tumor necrosis factor (TNF)-α, interleukin-6 (IL-6), interferon (IFN)-β, and IFN-γ at diagnosis. The other neonate had no fever or TNF-α production, but significant IL-6 or IFN responses during the treatment course, and died 19 days after birth. Among 16 reported cases of neonatal HSV-HLH including index cases, eight deceased neonates experienced significantly less fever at presentation (p = 0.028), lower platelet counts (p = 0.019), and lower ratios of soluble IL-2 receptor (sIL-2R) to ferritin levels (p = 0.044) than eight survivors. The 100-day overall survival rates were significantly higher in patients with fever (p = 0.004), > 100 × 10
Identifiants
pubmed: 31549293
doi: 10.1007/s12185-019-02738-3
pii: 10.1007/s12185-019-02738-3
doi:
Substances chimiques
Interleukin-6
0
Receptors, Interleukin-2
0
Toll-Like Receptor 3
0
Tumor Necrosis Factor-alpha
0
Interferon-beta
77238-31-4
Interferon-gamma
82115-62-6
Ferritins
9007-73-2
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
131-136Subventions
Organisme : Japan Agency for Medical Research and Development
ID : 16ek0109099
Organisme : Japan Agency for Medical Research and Development
ID : 16ek0109098h0002
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