Distinct Chemotaxis Protein Paralogs Assemble into Chemoreceptor Signaling Arrays To Coordinate Signaling Output.


Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
24 09 2019
Historique:
entrez: 26 9 2019
pubmed: 26 9 2019
medline: 30 4 2020
Statut: epublish

Résumé

Most chemotactic motile bacteria possess multiple chemotaxis signaling systems, the functions of which are not well characterized. Chemotaxis signaling is initiated by chemoreceptors that assemble as large arrays, together with chemotaxis coupling proteins (CheW) and histidine kinase proteins (CheA), which form a baseplate with the cytoplasmic tips of receptors. These cell pole-localized arrays mediate sensing, signaling, and signal amplification during chemotaxis responses. Membrane-bound chemoreceptors with different cytoplasmic domain lengths segregate into distinct arrays. Here, we show that a bacterium,

Identifiants

pubmed: 31551333
pii: mBio.01757-19
doi: 10.1128/mBio.01757-19
pmc: PMC6759762
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Carrier Proteins 0
Membrane Proteins 0
Methyl-Accepting Chemotaxis Proteins 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 O’Neal et al.

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Auteurs

Lindsey O'Neal (L)

Department of Biochemistry, Cellular & Molecular Biology, The University of Tennessee, Knoxville, Tennessee, USA.

Jessica M Gullett (JM)

Department of Biochemistry, Cellular & Molecular Biology, The University of Tennessee, Knoxville, Tennessee, USA.

Anastasia Aksenova (A)

Department of Biochemistry, Cellular & Molecular Biology, The University of Tennessee, Knoxville, Tennessee, USA.

Adam Hubler (A)

Department of Biochemistry, Cellular & Molecular Biology, The University of Tennessee, Knoxville, Tennessee, USA.

Ariane Briegel (A)

Department of Biology, California Institute of Technology, Pasadena, California, USA.

Davi Ortega (D)

Department of Biology, California Institute of Technology, Pasadena, California, USA.

Andreas Kjær (A)

Department of Biology, California Institute of Technology, Pasadena, California, USA.

Grant Jensen (G)

Department of Biology, California Institute of Technology, Pasadena, California, USA.

Gladys Alexandre (G)

Department of Biochemistry, Cellular & Molecular Biology, The University of Tennessee, Knoxville, Tennessee, USA galexan2@utk.edu.

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Classifications MeSH