Loss of Janus Associated Kinase 1 Alters Urothelial Cell Function and Facilitates the Development of Bladder Cancer.
Biomarkers
Cell Line, Tumor
Cytotoxicity, Immunologic
Disease Susceptibility
Epithelial Cells
/ metabolism
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Interferon-gamma
/ metabolism
Janus Kinase 1
/ deficiency
Lymphocytes
/ immunology
Mucous Membrane
/ immunology
RNA, Messenger
/ genetics
STAT1 Transcription Factor
/ metabolism
Telomerase
/ genetics
Urinary Bladder Neoplasms
/ etiology
IFNγ signaling
JAK1
bladder cancer
immunodeficiency
urothelium
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
08
02
2019
accepted:
15
08
2019
entrez:
26
9
2019
pubmed:
26
9
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Inherited Primary Immunodeficiency (PID) disorders are associated with increased risk of malignancy that may relate to impaired antitumor immune responses or a direct role for PID germline mutations in tumorigenesis. We recently identified germline loss of function mutations in Janus Associated Kinase 1 (
Identifiants
pubmed: 31552026
doi: 10.3389/fimmu.2019.02065
pmc: PMC6746825
doi:
Substances chimiques
Biomarkers
0
RNA, Messenger
0
STAT1 Transcription Factor
0
Interferon-gamma
82115-62-6
JAK1 protein, human
EC 2.7.10.2
Janus Kinase 1
EC 2.7.10.2
TERT protein, human
EC 2.7.7.49
Telomerase
EC 2.7.7.49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2065Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104807/Z/14/Z
Pays : United Kingdom
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