IFN-γ enhances cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus.
Apoptosis
/ drug effects
Cytotoxicity, Immunologic
/ drug effects
Epidermis
/ pathology
Histocompatibility Antigens Class I
/ metabolism
Humans
Inflammation
/ pathology
Interferon-gamma
/ pharmacology
Janus Kinase 2
/ metabolism
Keratinocytes
/ drug effects
Lichen Planus
/ genetics
STAT1 Transcription Factor
/ metabolism
Signal Transduction
/ drug effects
Transcriptome
/ genetics
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
25 09 2019
25 09 2019
Historique:
received:
17
10
2018
revised:
31
01
2019
accepted:
02
08
2019
entrez:
27
9
2019
pubmed:
27
9
2019
medline:
21
8
2020
Statut:
ppublish
Résumé
Lichen planus (LP) is a chronic debilitating inflammatory disease of unknown etiology affecting the skin, nails, and mucosa with no current FDA-approved treatments. It is histologically characterized by dense infiltration of T cells and epidermal keratinocyte apoptosis. Using global transcriptomic profiling of patient skin samples, we demonstrate that LP is characterized by a type II interferon (IFN) inflammatory response. The type II IFN, IFN-γ, is demonstrated to prime keratinocytes and increase their susceptibility to CD8
Identifiants
pubmed: 31554739
pii: 11/511/eaav7561
doi: 10.1126/scitranslmed.aav7561
pmc: PMC7285657
mid: NIHMS1583136
pii:
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
STAT1 Transcription Factor
0
Interferon-gamma
82115-62-6
Janus Kinase 2
EC 2.7.10.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR057216
Pays : United States
Organisme : NIAMS NIH HHS
ID : K08 AR060802
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR007197
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK081943
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR075043
Pays : United States
Organisme : NIAMS NIH HHS
ID : K01 AR072129
Pays : United States
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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