High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program.
Aged
Animals
Cell Line, Tumor
Cell Proliferation
/ drug effects
Diet, High-Fat
/ adverse effects
Disease Progression
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Male
Metabolome
/ drug effects
Mice, Transgenic
Middle Aged
Prostatic Neoplasms
/ etiology
Proto-Oncogene Proteins c-myc
/ genetics
Tumor Burden
/ drug effects
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
25 09 2019
25 09 2019
Historique:
received:
06
09
2018
accepted:
23
08
2019
entrez:
27
9
2019
pubmed:
27
9
2019
medline:
14
1
2020
Statut:
epublish
Résumé
Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. Here, we demonstrate in a murine prostate cancer model, that high-fat diet (HFD) enhances the MYC transcriptional program through metabolic alterations that favour histone H4K20 hypomethylation at the promoter regions of MYC regulated genes, leading to increased cellular proliferation and tumour burden. Saturated fat intake (SFI) is also associated with an enhanced MYC transcriptional signature in prostate cancer patients. The SFI-induced MYC signature independently predicts prostate cancer progression and death. Finally, switching from a high-fat to a low-fat diet, attenuates the MYC transcriptional program in mice. Our findings suggest that in primary prostate cancer, dietary SFI contributes to tumour progression by mimicking MYC over expression, setting the stage for therapeutic approaches involving changes to the diet.
Identifiants
pubmed: 31554818
doi: 10.1038/s41467-019-12298-z
pii: 10.1038/s41467-019-12298-z
pmc: PMC6761092
doi:
Substances chimiques
Proto-Oncogene Proteins c-myc
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
4358Subventions
Organisme : NCI NIH HHS
ID : R01 CA215452
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA090381
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA187918
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA090598
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL034595
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA167552
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA155626
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA058684
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA167552
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA040360
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK046200
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA131945
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA042182
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL026490
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA097193
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA163227
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA034944
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA141298
Pays : United States
Commentaires et corrections
Type : CommentIn
Références
Cell. 2011 Dec 23;147(7):1628-39
pubmed: 22196736
Nat Med. 2016 Apr;22(4):369-78
pubmed: 26928463
Genes Dev. 2008 Oct 15;22(20):2755-66
pubmed: 18923074
JAMA Intern Med. 2013 Jul 22;173(14):1318-26
pubmed: 23752662
Prostate Cancer Prostatic Dis. 2017 Mar;20(1):28-35
pubmed: 27801901
Lancet. 2014 Aug 30;384(9945):766-81
pubmed: 24880830
JAMA. 2012 Nov 14;308(18):1871-80
pubmed: 23162860
Bioinformatics. 2006 Aug 1;22(15):1924-5
pubmed: 16709585
Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):255-60
pubmed: 25371445
Bioinformatics. 2001 Jun;17(6):520-5
pubmed: 11395428
Cold Spring Harb Perspect Med. 2018 Oct 1;8(10):
pubmed: 29229664
Oncogene. 2012 Jul 19;31(29):3444-56
pubmed: 22120715
Cancer Causes Control. 1999 Aug;10(4):245-51
pubmed: 10482482
Lancet. 2011 Jul 2;378(9785):31-40
pubmed: 21705069
Cold Spring Harb Perspect Med. 2018 Nov 1;8(11):
pubmed: 29530947
Genome Biol. 2009;10(3):R25
pubmed: 19261174
Mol Metab. 2015 Jan 02;4(3):186-98
pubmed: 25737954
Lancet Oncol. 2011 Mar;12(3):245-55
pubmed: 21310658
Science. 2017 Jan 6;355(6320):78-83
pubmed: 28059767
Cancer Cell. 2010 Jul 13;18(1):11-22
pubmed: 20579941
Clin Cancer Res. 2006 Jul 1;12(13):3961-70
pubmed: 16818693
Oncogene. 2015 Sep 3;34(36):4683-91
pubmed: 25531313
Biostatistics. 2003 Apr;4(2):249-64
pubmed: 12925520
Int J Cancer. 2007 Oct 1;121(7):1571-8
pubmed: 17450530
JAMA. 2009 Jan 7;301(1):52-62
pubmed: 19066368
Cancer Discov. 2015 Oct;5(10):1024-39
pubmed: 26382145
PLoS One. 2016 Aug 03;11(8):e0159109
pubmed: 27487262
Cancer Res. 2016 Jun 1;76(11):3130-5
pubmed: 27020859
Nucleic Acids Res. 2003 Feb 15;31(4):e15
pubmed: 12582260
Nat Rev Genet. 2006 Sep;7(9):715-27
pubmed: 16983801
Anal Chem. 2009 Aug 15;81(16):6656-67
pubmed: 19624122
J Biol Chem. 2010 Nov 19;285(47):36267-74
pubmed: 20813845
Cancer Prev Res (Phila). 2011 Dec;4(12):2002-14
pubmed: 21952584
Genome Biol. 2012 Nov 27;13(11):R110
pubmed: 23186133
Curr Opin Biotechnol. 2015 Aug;34:23-9
pubmed: 25461508
Nat Genet. 2018 Feb;50(2):206-218
pubmed: 29335545
Int J Radiat Oncol Biol Phys. 2014 Aug 1;89(5):1038-1046
pubmed: 25035207
Oncogene. 2009 Jul 9;28(27):2485-91
pubmed: 19448666
Am J Pathol. 2012 Aug;181(2):560-9
pubmed: 22713676
Cancer Res. 2014 Dec 15;74(24):7198-204
pubmed: 25322691
Cancer Epidemiol Biomarkers Prev. 2018 Feb;27(2):201-207
pubmed: 29141848
Int J Cancer. 2008 Jun 1;122(11):2581-5
pubmed: 18324626
Cancer. 2017 Nov 1;123(21):4130-4138
pubmed: 28700821
Anal Chem. 2013 Jun 4;85(11):5288-96
pubmed: 23590404
J Biol Chem. 2014 Sep 5;289(36):25382-92
pubmed: 25053415
Nature. 2013 Oct 24;502(7472):489-98
pubmed: 24153302
Mol Cell. 2016 Jun 2;62(5):695-711
pubmed: 27259202
J Clin Oncol. 2009 Jul 20;27(21):3459-64
pubmed: 19433685
Nat Genet. 2013 Nov;45(11):1386-91
pubmed: 24076604
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Cell Metab. 2012 Jul 3;16(1):9-17
pubmed: 22768835
Cancer Causes Control. 2015 Aug;26(8):1117-26
pubmed: 26047644
Eur Urol. 2016 Jan;69(1):157-65
pubmed: 26058959
Mod Pathol. 2008 Sep;21(9):1156-67
pubmed: 18567993
N Engl J Med. 1996 May 2;334(18):1145-9
pubmed: 8602179
Methods. 2015 Jan 15;72:57-64
pubmed: 25448295
Nature. 2014 Jul 24;511(7510):483-7
pubmed: 25043018
Cancer Res. 2005 Dec 15;65(24):11565-71
pubmed: 16357166
Cancer Res. 2008 Apr 15;68(8):3066-73
pubmed: 18413778
N Engl J Med. 1989 Jul 20;321(3):129-35
pubmed: 2664509
Cancer Cell. 2003 Sep;4(3):223-38
pubmed: 14522256
Nature. 2010 Jul 22;466(7305):503-7
pubmed: 20622853
Endocr Relat Cancer. 2015 Dec;22(6):R365-86
pubmed: 26373570
Nat Biotechnol. 2011 Jan;29(1):24-6
pubmed: 21221095
Semin Cell Dev Biol. 2015 Jul;43:11-21
pubmed: 26277543
Cold Spring Harb Perspect Med. 2013 Aug 01;3(8):
pubmed: 23906881
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W187-91
pubmed: 24799436
Cancer Prev Res (Phila). 2011 Apr;4(4):486-501
pubmed: 21233290
Cell. 2015 Nov 5;163(4):1011-25
pubmed: 26544944
Lancet. 2011 Feb 12;377(9765):578-86
pubmed: 21295847
Am J Epidemiol. 1992 May 15;135(10):1114-26; discussion 1127-36
pubmed: 1632423
Onco Targets Ther. 2015 Aug 10;8:1979-88
pubmed: 26309412
Rev Urol. 2004 Fall;6(4):171-9
pubmed: 16985598
J Urol. 2013 Dec;190(6):2047-53
pubmed: 23770138
CA Cancer J Clin. 2017 Jan;67(1):7-30
pubmed: 28055103
Eur Urol. 2016 Oct;70(4):588-596
pubmed: 26806658
J Cheminform. 2010 Oct 18;2(1):9
pubmed: 20955607
Curr Opin Chem Biol. 2016 Feb;30:52-60
pubmed: 26629854
Mol Cell Biol. 2010 Jul;30(13):3286-98
pubmed: 20421419
Nat Rev Cancer. 2016 Nov;16(11):694-707
pubmed: 27634449