Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects.
Animals
Anti-Bacterial Agents
/ pharmacology
Colitis
/ enzymology
Colon
/ drug effects
Cytochrome b Group
/ deficiency
Disease Models, Animal
Dysbiosis
Female
Gastrointestinal Microbiome
Immunity, Innate
Immunity, Mucosal
Intestinal Mucosa
/ drug effects
Male
Mice, Inbred C57BL
Mice, Knockout
Mice, Mutant Strains
Mucus
/ enzymology
Mutation, Missense
NADPH Oxidases
/ deficiency
Reactive Oxygen Species
/ metabolism
Signal Transduction
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
02
07
2019
accepted:
06
09
2019
revised:
13
08
2019
pubmed:
27
9
2019
medline:
28
4
2020
entrez:
27
9
2019
Statut:
ppublish
Résumé
Reactive oxygen species (ROS) generated by NADPH oxidases (NOX/DUOX) provide antimicrobial defense, redox signaling, and gut barrier maintenance. Inactivating NOX variants are associated with comorbid intestinal inflammation in chronic granulomatous disease (CGD; NOX2) and pediatric inflammatory bowel disease (IBD; NOX1); however Nox-deficient mice do not reflect human disease susceptibility. Here we assessed if a hypomorphic patient-relevant CGD mutation will increase the risk for intestinal inflammation in mice. Cyba (p22
Identifiants
pubmed: 31554901
doi: 10.1038/s41385-019-0205-x
pii: S1933-0219(22)00452-4
doi:
Substances chimiques
Anti-Bacterial Agents
0
Cytochrome b Group
0
Reactive Oxygen Species
0
NADPH Oxidases
EC 1.6.3.-
Cyba protein, mouse
EC 1.6.3.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1316-1326Subventions
Organisme : Medical Research Council
ID : MR/P009824/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC/PC/15077
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P009824/1
Pays : United Kingdom
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