Both hypo- and hyperglycaemia are associated with increased fracture risk in Japanese people with type 2 diabetes: the Fukuoka Diabetes Registry.
Journal
Diabetic medicine : a journal of the British Diabetic Association
ISSN: 1464-5491
Titre abrégé: Diabet Med
Pays: England
ID NLM: 8500858
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
accepted:
23
09
2019
pubmed:
27
9
2019
medline:
8
9
2021
entrez:
27
9
2019
Statut:
ppublish
Résumé
The impact of glycaemic control on fracture risk is controversial, which may be due to the possible presence of hypoglycaemia. The aim of this study was to separately investigate the impacts of severe hypoglycaemia and poor glycaemic control on fracture risk in people with type 2 diabetes. Overall, 4706 Japanese participants (2755 men and 1951 postmenopausal women) with type 2 diabetes (mean age 66 years) were followed prospectively (a median of 5.3 years; follow-up rate, 97.6%), and were stratified by severe hypoglycaemia status and glycaemic control. The primary outcome was fractures at any anatomic site. Fractures occurred in 662 participants (249 men and 413 women). The age- and sex-adjusted incidence rates (expressed per 1000 person-years) were: 71.2 (multiple episodes of severe hypoglycaemia), 43.1 (one episode), 25.2 [HbA Both severe hypoglycaemia and poor glycaemic control were significantly related to an increased risk of fracture in people with type 2 diabetes, although severe hypoglycaemia conferred a stronger risk.
Substances chimiques
Hypoglycemic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
838-847Subventions
Organisme : Japan Society for the Promotion of Science KAKENHI
Pays : International
Organisme : Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : 23249037
Pays : International
Organisme : Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : 23659353
Pays : International
Organisme : Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : 16K00861
Pays : International
Organisme : Junior Scientist Development Grant supported by the Japan Diabetes Society
Pays : International
Organisme : Lilly Research Grant Program for Bone & Mineral Research
Pays : International
Informations de copyright
© 2019 Diabetes UK.
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